Cesium-associated hypokalemia successfully treated with amiloride

Horn, Sarah; Naidus, Elliot; Alper, Seth L.; Danziger, John

doi:10.1093/ckj/sfv017

Cited by 15 publications

(12 citation statements)

References 33 publications

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“…[11][12][13][14][15] Importantly, Cai et al 15 found a significant reduction in serum levels of the alkali metal cesium in individuals with SCZ in comparison with healthy controls. This may be important because cesium shares some similarities with potassium, and therefore may interfere with potassium metabolism, 16 while a single nucleotide polymorphism (SNP) in the KCNH2 gene, which encodes the pore-forming subunit of potassium channels, has been associated with SCZ and with cognitive impairments. 17 Moreover, cesium, rhenium, and rubidium were previously assayed in sera of patients with another immune-inflammatory illness, namely rheumatoid arthritis, with cesium found to be decreased in patients as compared with healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments

Almulla

Moustafa

Al-Dujaili

et al. 2021

Braz. J. Psychiatry

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Objectives: A previous study has shown that schizophrenia (SCZ) is accompanied by lowered levels of trace/metal elements, including cesium. However, it is not clear whether changes in cesium, rubidium, and rhenium are associated with activated immune-inflammatory pathways, cognitive impairments, and the symptomatology of SCZ. Methods: This study measured cesium, rubidium, and rhenium, cognitive impairments (using the Brief Assessment of Cognition in Schizophrenia [BACS]), and the levels of cytokines/chemokines interleukin (IL)-1b, tumor necrosis factor (TNF)-a, and eotaxin (CCL11) in 120 patients with SCZ and 54 healthy controls. Severity of illness was assessed using the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Negative Symptoms (SANS), the Fibromyalgia and Chronic Fatigue Syndrome Rating (FF) Scale, and the Hamilton Depression Rating Scale (HAM-D). Results: Serum cesium was significantly lower in patients with SCZ as compared with controls. Further, serum cesium was significantly and inversely associated with CCL11 and TNF-a, but not IL-1b, in patients with SCZ; significant inverse associations were also noted between serum cesium levels and BPRS, FF, HAM-D, and SANS scores. Finally, cesium was positively correlated with neurocognitive probe results including the Tower of London, Symbol Coding, Controlled Word Association, Category Instances, Digit Sequencing Task, and List Learning tests. Conclusion:The results suggest that lowered serum cesium levels may play a role in the pathophysiology of SCZ, contributing to specific symptom domains including negative, depressive and fatigue symptoms, neurocognitive impairments (spatial working, episodic, and semantic memory and executive functions), and neuroimmune pathways.

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Section: Introductionmentioning

confidence: 99%

Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments

Almulla

Moustafa

Al-Dujaili

et al. 2021

Braz. J. Psychiatry

View full text Add to dashboard Cite

show abstract

“…Importantly, Cai et al found a significant reduction in serum levels of the alkali metal cesium in SCZ patients in comparison with healthy controls 15 . This may be important because cesium shares some similarities with potassium and, therefore, may interfere with potassium metabolism 16 while there is some evidence that the KCNH2 SNP, which encodes the pore-forming subunit of potassium channels, is associated with schizophrenia and with cognitive impairments 17 . Moreover, cesium, rhenium, and rubidium were previously assayed in sera of patients with another immune-inflammatory illness, namely rheumatoid arthritis, and of those three metals cesium was found to be decreased in patients as compared with healthy controls 18 .…”

Section: Introductionmentioning

confidence: 99%

Lowered Serum Cesium Levels in Schizophrenia: Association with Immune-Inflammatory Biomarkers and Cognitive Impairments

Almulla

Moustafa

Al-Dujaili

et al. 2020

Preprint

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Objective: A previous study showed that schizophrenia is accompanied by lowered levels of trace/metal elements including cesium. There are no data whether changes in cesium, rubidium and rhenium are associated with activated immune-inflammatory pathways, cognitive impairments, and the symptomatology of schizophrenia. Methods: This study measured cesium, rubidium, and rhenium, cognitive impairments (using the Brief Assessment of Cognition in Schizophrenia) and the cytokines/chemokines interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and CCL11 (eotaxin) in 120 schizophrenia patients and 54 healthy controls. Severity of illness was assessed using the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Negative Symptoms (SANS), the Fibromyalgia and Chronic Fatigue Syndrome Rating (FF) Scale and the Hamilton Depression Rating Scale (HAM-D). Results: Serum cesium was significantly lower in schizophrenia patients as compared with controls. Serum cesium was significantly and inversely associated with CCL11 and TNF-α, but not IL-1β. Moreover, there were significant inverse associations between serum cesium levels and the BPRS, FF, HAM-D and SANS scores and positive correlations between cesium and neurocognitive probe results including the Tower of London, Symbol Coding, Controlled Word Association, Category Instances, Digit Sequencing Task, and List Learning tests. Conclusion: The results suggest that lowered serum cesium levels may play a role in the pathophysiology of SCZ, specific symptom domains including negative, depressive and fatigue symptoms, neurocognitive impairments (spatial working, episodic and semantic memory and executive functions) and neuro-immune pathways as well.

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“…Metallic cesium form is used in a variety of products for example, Atomic Clocks, carbon dioxide purification; and ion cesium form is used in Biotechnology and Medicine for example, purification of nucleic acids, i.e., RNA and DNA viruses (22).Cesium chloride for cancer treatment has never been approved by the US Food and Drug Administration (FDA). It may cause serious cardiac arrhythmias, prolonged QTC interval (24), hypokalemia (25) and accumulation in brain (26), and has impact on Thyroid Function (27).Silver and Cesium determination in water is performed by different methods. The present study measured the level of Cesium and Silver in drinking water by FGAAS which is a micro-amount sample analysis method with high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Cesium and silver levels in the water at the inlet to the bottled water factories and water treatment plant No. 2 in Ahvaz City and outlet water of them after the water treatment process

2017

Int. J. Curr. Res. Chem. Pharm. Sci

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Cesium-associated hypokalemia successfully treated with amiloride

Cited by 15 publications

References 33 publications

Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments

Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments

Lowered Serum Cesium Levels in Schizophrenia: Association with Immune-Inflammatory Biomarkers and Cognitive Impairments

Comparison of Cesium and silver levels in the water at the inlet to the bottled water factories and water treatment plant No. 2 in Ahvaz City and outlet water of them after the water treatment process

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