Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk

Marron, Manuela; Boffetta, Paolo; Zhang, Zuo‐Feng; Заридзе, Давид; Wünsch-Filho, Victor; Winn, Deborah M.; Wei, Qingyi; Talamini, Renato; Szeszenia-Da̧browska, Neonila; Sturgis, Erich M.; Smith, Elaine; Schwartz, Stephen M.; Rudnai, Péter; Purdue, Mark P.; Olshan, Andrew F.; Eluf-Neto, José; Muscat, Joshua E.; Morgenstern, Hal; Menezes, Ana; McClean, Michael D.; Matos, Elena; Mateș, Ioan Nicolae; Lissowska, Jolanta; Levi, Fabio; Lazarus, Philip; Vecchia, Carlo La; Koifman, Sérgio; Kelsey, Karl T.; Herrero, Rolando; Hayes, Richard B.; Franceschi, Silvia; Fernández, Leticia; Fabiánovà, Eleonóra; Daudt, Alexander W.; Maso, Luigino Dal; Curado, María Paula; Cadoni, Gabriella; Chen, Chu; Castellsagué, Xavier; Boccia, Stefania; Benhamou, Simone; Ferro, Gilles; Berthiller, Julien; Brennan, Paul; Møller, Henrik; Hashibe, Mia

doi:10.1093/ije/dyp291

Cited by 220 publications

(149 citation statements)

References 23 publications

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“…[34][35][36][37] Such a reduction, however, is observed in the long term, and its impact on the results is likely to be modest. 38 The interaction between alcohol consumption and tobacco smoking, the joint effect of which is multiplicative on head and neck cancers and esophageal SCC, 39,40 was not considered to estimate the burden of alcohol. Consequently, an important proportion of cases of these cancers could be attributed to either alcohol consumption or tobacco smoking, but this does not reduce the importance of the role of alcohol.…”

Section: Discussionmentioning

confidence: 99%

Cancer incidence and mortality attributable to alcohol consumption

Praud

Rota

Rehm

et al. 2015

Intl Journal of Cancer

180

138

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Alcohol consumption is a major cause of disease and death. In a previous study, we reported that in 2002, 3.6% of all cases of cancer and a similar proportion of cancer deaths were attributable to the consumption of alcohol. We aimed to update these figures to 2012 using global estimates of cancer cases and cancer deaths, data on the prevalence of drinkers from the World Health Organization (WHO) global survey on alcohol and health, and relative risks for alcohol-related neoplasms from a recent meta-analysis. Over the 10-year period considered, the total number of alcohol-attributable cancer cases increased to approximately 770,000 worldwide (5.5% of the total number of cancer cases)-540,000 men (7.2%) and 230,000 women (3.5%). Corresponding figures for cancer deaths attributable to alcohol consumption increased to approximately 480,000 (5.8% of the total number of cancer deaths) in both sexes combined-360,000 (7.8%) men and 120,000 (3.3%) women. These proportions were particularly high in the WHO Western Pacific region, the WHO European region and the WHO South-East Asia region. A high burden of cancer mortality and morbidity is attributable to alcohol, and public health measures should be adopted in order to limit excessive alcohol consumption.In 2012, 38.1% of the world's population aged 15 years or older were estimated to be regular drinkers, with an average consumption among drinkers of 38.6 g of pure alcohol per day (approximately 3.2 drinks) (calculations based on http:// www.who.int/gho/alcohol/en/; see also Ref. 1); however, there was considerable variation in the prevalence of drinking across the regions of the world.1 Alcohol is one of the primary risk factors for morbidity, disability and mortality worldwide. 1 The impact of alcohol consumption on head and neck cancers and on esophageal squamous cell carcinoma (SCC) has long been known, 2 even at low levels of consumption, 3 but the number of cancers associated with alcohol consumption has increased in recent years, and currently includes cancers of the colon, rectum, liver, female breast 4 and with limited evidence and for high levels of consumption, pancreas.5 Moreover, a recent meta-analysis suggested a weak positive association between alcohol consumption and cancers of the gallbladder, prostate, lung, stomach and melanoma. 6 In a previous study, we reported that in 2002, 3.6% of all cancer cases and a similar proportion of cancer deaths were attributable to alcohol. 7 We aimed to update these results to 2012 and estimate the worldwide burden of cancer attributable to alcohol by combining up-to-date relative risk (RR) estimates of cancer, the global prevalence of drinkers and global estimates of cancer cases and cancer deaths. MethodsWe computed the overall and sex-specific number of cases and deaths of the main alcohol-related cancers, 6 including oral cavity and pharynx, esophagus (SCC only), colon and

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Section: Discussionmentioning

confidence: 99%

Cancer incidence and mortality attributable to alcohol consumption

Praud

Rota

Rehm

et al. 2015

Intl Journal of Cancer

180

138

View full text Add to dashboard Cite

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“…Por tanto, las estrategias de prevención primaria en salud son claves a la hora de generar un impacto en la incidencia del carcinoma escamoso de laringe. En términos generales, se ha estimado que la suspensión del tabaquismo entre 1 a 4 años sería capaz de reducir el riesgo de carcinoma escamoso hasta en 30%, aumentando al 77% si la suspensión es por un periodo de 20 años, riesgo similar al de personas que nunca han fumado 21 . Se ha mencionado que el riesgo atribuible porcentual poblacional del consumo de tabaco es del 24% 22 .…”

Section: Factores De Riesgo Y Prevenciónunclassified

“…Se ha mencionado que el riesgo atribuible porcentual poblacional del consumo de tabaco es del 24% 22 . Para el consumo de alcohol, se ha observado un beneficio a 20 años de suspendido con una reducción del 40% de riesgo 21 .…”

Section: Factores De Riesgo Y Prevenciónunclassified

Importancia de la epidemiología en cáncer laríngeo: Incidencia y mortalidad por carcinoma escamoso de laringe

2017

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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“…A prevenção primária visa a ações ou iniciativas que possam reduzir a incidência e a prevalência da doença, modificando os hábitos da comunidade, buscando interromper ou diminuir os fatores de risco como o tabaco, o álcool e a exposição solar dos lábios, antes mesmo que a doença se instale 21,22 . A prevenção secundária visa ao diagnóstico precoce da doença em uma fase anterior ao paciente apresentar alguma queixa clínica.…”

Section: Prevenção Primária Do Câncer Da Bocaunclassified

Abordagem do câncer da boca: uma estratégia para os níveis primário e secundário de atenção em saúde

et al. 2012

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O avanço verificado no enfrentamento de neoplasias malignas por meio dos sistemas de saúde envolve melhorias nas áreas de vigilância, organização de redes de assistência, programas específicos voltados às prevenções primária e secundária e, obviamente, aos avanços técnico-científicos que caracterizam a abordagem diagnóstica e terapêutica. Embora seja notável o reconhecimento de avanços no manejo de neoplasias malignas em todas as áreas citadas, o câncer da boca permanece com indicadores de morbidade e mortalidade que parecem não acompanhar o acúmulo científico no conhecimento da doença. O presente manuscrito objetiva discutir os motivos desse descompasso, a necessidade de reorientação de prioridades na abordagem do câncer da boca e sua efetivação como política pública de saúde.

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Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk

Abstract: Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer.

Cited by 220 publications

References 23 publications

Cancer incidence and mortality attributable to alcohol consumption

Cancer incidence and mortality attributable to alcohol consumption

Importancia de la epidemiología en cáncer laríngeo: Incidencia y mortalidad por carcinoma escamoso de laringe

Abordagem do câncer da boca: uma estratégia para os níveis primário e secundário de atenção em saúde

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