Cessation of voluntary wheel running increases anxiety-like behavior and impairs adult hippocampal neurogenesis in mice

Nishijima, Takeshi; Llorens‐Martin, María; Tejeda, Gonzalo S.; Inoue, Koshiro; Yamamura, Yuhei; Soya, Hideaki; Trejo, José Luís; Torres‐Alemán, Ignacio

doi:10.1016/j.bbr.2013.02.009

Cited by 68 publications

(65 citation statements)

References 57 publications

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“…They also performed the same experiment in adult rats that started wheel running at 9 weeks old and did not find a significant reduction in BDNF protein levels following exercise cessation, suggesting that the effects might depend on the age that the animals experienced wheel running. Collectively, these results support our current findings that hippocampal adaptation to physical inactivity may not be a simple reversal of a prior adaptation to physical exercise, which could impair hippocampal function 49) .…”

Section: Impacts Of Physical Inactivity On Rodent Hippocampussupporting

confidence: 80%

“…With this approach, reduced physical activity following cessation of (Fig. 3B) 49) . This finding suggests the surprising possibility that hippocampal changes in response to physical inactivity are not merely a reverse adaptation to beneficial changes due to prior exercise; rather, it is more likely that a reduction in physical activity can impair hippocampal function.…”

Section: Impacts Of Physical Inactivity On Rodent Hippocampusmentioning

confidence: 99%

“…We have been attempting to understand the impact of physical inactivity on the hippocampus by using a model of cessation of habituated voluntary wheel running, a reverse intervention to control mouse physical activity 49) . Briefly, post-weaned mice are reared in a cage with a running wheel until early adulthood (8 weeks, from 4 to 11 weeks of age) and subsequently placed in a standard laboratory cage (Fig.…”

Section: Impacts Of Physical Inactivity On Rodent Hippocampusmentioning

confidence: 99%

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Deleterious effects of physical inactivity on the hippocampus: New insight into the increasing prevalence of stress-related depression

Nishijima

Kita

2015

JPFSM

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Populations worldwide are increasingly becoming physically inactive, which is related to somatic and psychological health problems that are prevalent in modern society. Recent epidemiological studies have indicated that the associations between physical inactivity and depression are bidirectional. Numerous animal studies have demonstrated that exercise improves hippocampal function. Because the hippocampus is a pivotal brain region that exerts inhibitory control over stress responses by affecting the hypothalamus-pituitary-adrenal axis, enhanced hippocampal function by exercise can increase stress resilience, which helps prevent stress-related depression. In contrast, physical inactivity is difficult to model in animal studies, and little is known about the effects of physical inactivity on the rodent hippocampus. To fill this gap, we previously developed a mouse model of habituated voluntary wheel running cessation as a reverse intervention to control physical activity. We found that reducing physical activity by cessation of wheel running impairs hippocampal neurogenesis in mice. Thus, this review discusses the relevant literature and provides a hypothesis that physical inactivity can be a potential risk factor for stress-related depression as it increases stress vulnerability by impairing hippocampal function.

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Section: Impacts Of Physical Inactivity On Rodent Hippocampussupporting

confidence: 80%

Section: Impacts Of Physical Inactivity On Rodent Hippocampusmentioning

confidence: 99%

Section: Impacts Of Physical Inactivity On Rodent Hippocampusmentioning

confidence: 99%

See 1 more Smart Citation

Deleterious effects of physical inactivity on the hippocampus: New insight into the increasing prevalence of stress-related depression

Nishijima

Kita

2015

JPFSM

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“…It has been reported that chronic exposure to opiate could significantly decrease neurogenesis and produce dendritic atrophy or neurodegeneration, alter synaptic transmission in the hippocampus (1,4). Attenuation of adult neurogenesis interferes with learning of a hippocampus-dependent task and expression of long-term potentiation (LTP) in vitro (1,5), and increases a vulnerability to anxiety-like behaviors (6). In human subjects and in rodents, voluntary or forced exercises promote neurogenesis in the adult dentate gyrus (DG) (7) and brain-derived neurotrophic factor (BDNF) might have a potential role in exercise-induced neurogenesis, synaptic plasticity, and memory through its actions on the tyrosine kinase B (TrkB) receptor (8)(9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Enhancing Hippocampal Neuronal Numbers in Morphine-Dependent Rats by Voluntary Exercise Through a Brain-Derived Neurotrophic Factor-Mediated Mechanism

Rashidy-Pour

Fathollahi

Miladi‐Gorji

et al. 2015

Middle East J Rehabil Health

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Background: Exposure to morphine decreases neurogenesis in the hippocampus. Recent studies have shown that voluntary running decreases the severity of anxiety behaviors and cognitive deficits, and increased synaptic plasticity in morphine-dependent rats. Objectives: This study aimed to investigate whether the morphine dependence-induced attenuation of hippocampal neuron number in rats would be reversed by voluntary running through a brain-derived neurotrophic factor (BDNF)-mediated mechanism. Materials and Methods: The rats were received injections of 10 mg/kg of morphine twice a day over ten days of voluntary running. A specific antagonist of BDNF action (TrkB-IgG) was used to block the hippocampal BDNF action during the study period; cytochrome C (Cyt C) was used as the control drug. Results: We found that chronic exposure to morphine had decreased the number of dentate gyrus neurons in sedentary rats receiving Cyt C or IgG in comparison to the control rats (P < 0.05). Moreover, exercise groups receiving saline or morphine showed an increase in the number of neurons following ten days running; blocking the BDNF action with TrkB-IgG fully inhibited this effect (both, P = 0.0001). Conclusions: This study demonstrates that that voluntary exercise can ameliorate the attenuation of hippocampal neuron number induced by morphine dependence through a BDNF-mediated mechanism. Thus, physical activity might have a potential role in ameliorating chronic morphine-induced neuronal changes in the hippocampus.

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“…Therefore, as to the behavioral assessment, the research difficult is the complex behavior assessment of multiple elements variable, while the research hot spot of multiple elements variable behavioral assessment is the determination of relative weights of all the variables. The existing methods for determining the relative weights of multiple elements variable are expert assessment method [1,2], experience formula method [3,4], mean-variance method [5,6], and support-confidence method [7,8].…”

Section: Introductionmentioning

confidence: 99%

Dynamic behavioral assessment model based on Hebb learning rule

Yin

Yuan

Zhang

2016

Neural Comput & Applic

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Behavioral assessment based on computing system is with important value for computer-simulated training and system diagnosis. However, the existing assessment is a static method for ex post evaluation, and the low efficiency and high complexity have been the urgent problems to be solved in the academic field. In this paper, we propose an adaptive dynamic behavioral assessment model based on Hebb learning rule that effectively combines the assessment standard and the weights of factors. The dynamic behavioral assessment considers the relative weights between the assessment indexes, whereas the existing assessment method does not; the dynamic behavioral assessment uses the assessment standard data recursively and can conduct an instant assessment for the objectives. We have built an assessment system for computer-simulated training, and took the pilot behavioral assessment for example to test and verify the dynamic behavioral assessment mode. Experimental results show that the dynamic behavioral assessment model based on Hebb learning rule has more advantage in assessment efficiency and online computing support.

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Cessation of voluntary wheel running increases anxiety-like behavior and impairs adult hippocampal neurogenesis in mice

Cited by 68 publications

References 57 publications

Deleterious effects of physical inactivity on the hippocampus: New insight into the increasing prevalence of stress-related depression

Deleterious effects of physical inactivity on the hippocampus: New insight into the increasing prevalence of stress-related depression

Enhancing Hippocampal Neuronal Numbers in Morphine-Dependent Rats by Voluntary Exercise Through a Brain-Derived Neurotrophic Factor-Mediated Mechanism

Dynamic behavioral assessment model based on Hebb learning rule

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