Cetirizine: A New, Nonsedating Antihistamine

Barnes, Connie L.; McKenzie, Constance A.; Webster, Kathleen; Poinsett-Holmes, Kim

doi:10.1177/106002809302700414

Cited by 20 publications

(9 citation statements)

References 26 publications

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“…Ranitidina 150 mg 8 ore prima dell'esame Cetirizina 10 mg una cp 2 ore prima dell'esame e 4 ore dopo l'esame [4][5][6][7][8] Reazione probabile (presenza di 2 fattori di rischio minore) Profilassi mdc non ioni ci Deltacortene 50 mg 12 ore prima dell'esame Cetirizina 10 mg una cp 2 ore prima dell'esame e 4 ore dopo Reazione poco probabile (assenza di fattori di rischio)…”

Section: Discussioneunclassified

Reazioni avverse da mezzi di contrasto: Un modello di profilassi

Carchietti

Fabris

Valle

et al. 2001

Rivista di Neuroradiologia

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RIASSUNTO -La prevenzione delle reazioni avverse da mdc riveste un rilevante interesse diagnostico-terapeutico per le possibili complicanze anche gravi che si possono verificare e nel contempo presenta alcune difficoltà riconducibili alla necessità di identificare le persone "a rischio di reazione". Gli autori, dal 1998 hanno adottato un modello di medicina interattiva su CD-rom che, per mezzo di quesiti, guida il Neuroradiologo nella ricerca anamnestica e clinica di eventuali fattori di rischio, gli fornisce una valutazione probabilistica dell'eventuale rischio cui è esposto il paziente, la relativa profilassi, e gli propone specifici protocolli di trattamento in caso di reazione avversa. Su 6420 persone sottoposte a somministrazione di mdc negli ultimi tre anni (15 giugni 1997 -15 giugno 2000), 720 (11,2 %) hanno praticato la profilassi per reazione avversa per ipotesi di rischio maggiore (elevata probabilità di reazione).Risultati: Numero reazioni 6 (0,09%). Le persone che hanno presentato la reazione avversa non avevano praticato alcuna profilassi non essendo state identificate come "a rischio".Tipologia delle reazioni segnalate: Reazioni lievi n. 6 (100%). Tali evidenze permettono di sostenere che la profilassi farmacologica è in grado di prevenire un rilevante numero di reazioni avverse da mdc; che le procedure adottate ovvero l'adozione di modelli identificativi di probabilità di rischio con relativa profilassi farmacologica sono risultate adeguate; che l'adozione di un modello condiviso su ampia scala, con la identificazione di un centro di coordinamento e di analisi dei dati, permetterebbe di consolidare, mediante reports di grosso peso, convincimenti scientifici e scelte farmacologiche che possono tradursi in sicurezza operativa e corretta gestione economica nella diagnostica contrasto grafica. Adverse Reactions to Contrast Media: Preventive Models ComparedSUMMARY -Preventing adverse reactions to contrast media is important for diagnostic and therapeutic purposes in view of the severe complications which may ensue. However, prevention is difficult because of the need to identify persons at risk. Since 1998, we ha ve used an interactive CD-ROM medicine model of questions which guide neuroradiologists in history-taking and the clinical séarch for possible risk factors, providing a probabilistic assessment of the patient's possible risk, relative prevention and specific treatment protocol in case of an adverse reaction. aut of 6420 persons administered contrast media in the last three years (15th lune 1997-15th lune 2000),720 (11.2%) received preventive treatment against adverse reaction based on major risk (high probability of reaction).There were six adverse reactions, al! mild (0.09%). No prevention had been administered since these cases had not been identified as at risk.Our findings show that preventive medicai treatment can prevent a high number> of adverse reactions to contrast media. Models identifying the probability of risk with relative preventive management were appropriate. Adopting a widely ...

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Section: Discussioneunclassified

Reazioni avverse da mezzi di contrasto: Un modello di profilassi

Carchietti

Fabris

Valle

et al. 2001

Rivista di Neuroradiologia

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“…Cetirizine is an active carboxylic acid metabolite of hydroxyzine (fi rst generation antihistamine) (Barnes et al 1993). …”

Section: Meta-analysismentioning

confidence: 99%

The fetal safety of cetirizine: An observational cohort study and meta-analysis

Etwel

Djokanovic

Moretti

et al. 2014

Journal of Obstetrics and Gynaecology

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Cetirizine, a second-generation antihistamine, is an active metabolite of hydroxyzine used in the treatment of allergies, but the data on fetal safety are inconclusive. Pregnant women who were counselled by the 'Motherisk Program' regarding cetirizine exposure were enrolled in a cohort study and compared with pregnant women counselled for non-teratogenic exposures. The objective was to measure the rate of adverse pregnancy outcomes. Subsequently, we also conducted a meta-analysis of cohort studies that examined the pregnancy outcomes of women exposed to hydroxyzine or cetirizine during pregnancy. In the cohort study, there were no significant differences in the rates of major malformations between the cetirizine exposed and comparison group. In the meta-analysis, cetirizine was not associated with increased teratogenic risk. In contrast, a meta-analysis of cetirizine and hydroxyzine studies showed a marginal association with major malformations. Cetirizine is not associated with a clinically important increase in risk of adverse fetal outcomes.

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“…It is a metabolic product of bromhexine, used in a variety of respiratory disorders including chronic bronchitis and is also used in the Its molecular weight is 414.6 dissociation constant (pKa) 8.2 and half life is melting point is 235°C to 240°C [3,6]. Cetirizine is a selective, second-generation histamine H1 receptor antagonist [7,8]. Chemically cetirizine hydrochloride, 2-(2-(4-((4chlorophenyl)(phenyl)methyl)piperazin-1yl)ethoxy)acetic acid hydrochloride [8].…”

Section: Ambroxolmentioning

confidence: 99%

“…Cetirizine is a selective, second-generation histamine H1 receptor antagonist [7,8]. Chemically cetirizine hydrochloride, 2-(2-(4-((4chlorophenyl)(phenyl)methyl)piperazin-1yl)ethoxy)acetic acid hydrochloride [8]. It is white or almost white powder, freely soluble in water, practically insoluble in acetone and in methylene chloride [9,10].…”

Section: Ambroxolmentioning

confidence: 99%

Development and Stability Enhancement of Two Combine Drugs of Cetirizine and Ambroxol

Johar¹,

Chakraborty²,

Saini³

2018

IJTSRD

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Ambroxol Hydrochlorideand Cetirizine Hydrochloride are often prescribed together for greater patient acceptability, increased potency, multiple activity, fewer side effects and quick relief. AmbroxolHydrochloride and Cetirizine Hydrochloride are used for the treatment of bronchitis, cough, and allergy. Ambroxol and Cetirizine tablet available in the market are not suitable in certain cases such as motion sickness, sudden episodes of allergic attacks, or coughing and when drinking water is not available. Particularly these types of difficulty are pediatric and geriatric patients. An attempt has been made to develop and enhance the stability of two combine drugs Ambroxol Hydrochloride and Cetirizine Hydrochloride, we prepared fast disintegration tablets. Total six formulations (F1 were prepared to study the effect of superdisintegrants shown in Table I. Tablets were prepared technique of direct compression methods quantity of each ingredient was taken for each specified formulation. The superdisintegrant, sodium starch glycolate (1%, 2%, 4%, 6%, 8%, and 10%) concentration was used to develop the tablets. All the ingredients were passed through mesh the ingredients were cogrind in a pestle motor. talc and Sodium Stearyl fumarate were added and mixed for 5 minutes. The blended excipients were compressed into tablets using tablet compression machine (Madhur Industries, India). The dissolution studied results revealed that in both of the drug Ambroxol Hydrochloride and cetirizine hydrochlori in phosphate buffer pH 6.8 and pH 7.4 dissolution medium were shown within the specified Pharmacopoeias limit.

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Cetirizine: A New, Nonsedating Antihistamine

Abstract: Clinical studies indicate that cetirizine may be more beneficial in some ways than other available agents. Two of these advantages are a rapid onset of action and a once-daily dosing regimen. Future postmarketing surveillance is warranted to further document these findings.

Cited by 20 publications

References 26 publications

Reazioni avverse da mezzi di contrasto: Un modello di profilassi

Reazioni avverse da mezzi di contrasto: Un modello di profilassi

The fetal safety of cetirizine: An observational cohort study and meta-analysis

Development and Stability Enhancement of Two Combine Drugs of Cetirizine and Ambroxol

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