Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines

Xu,

doi:10.3892/or_00000819

Cited by 13 publications

(2 citation statements)

References 30 publications

(57 reference statements)

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“…Luo et al indicated that cetuximab enhanced the effect of OXA on gastric cancer cells via ERK/Akt pathways. 33 In addition, capilliposide C reversed OXA resistance in esophageal squamous carcinoma cells via downregulating the PI3K/Akt signaling pathway. 34 On the basis of the results, Tan IIA enhanced the sensitivity of SW480/OXA cells to OXA in vitro and in vivo by inhibiting Akt/ERK pathway.…”

Section: Dovepressmentioning

confidence: 98%

<p>Tanshinone IIA Reverses Oxaliplatin Resistance In Human Colorectal Cancer Via Inhibition Of ERK/Akt Signaling Pathway</p>

Zhang¹,

Ge²,

Xiang³

et al. 2019

OTT

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Background: Oxaliplatin (OXA)-based chemotherapy is generally used to treat human cancers, whereas OXA resistance is a main obstacle for the treatment of colorectal cancer (CRC). Evidence has shown that tanshinone IIA (Tan IIA) could induce apoptosis in CRC cells. However, the role of combination of OXA and Tan IIA on OXA-resistance CRC cells remains unknown. Thus, this study aimed to investigate the effects of Tan IIA in combination with OXA on OXA-resistance CRC cells. Methods: MTT assay, Ki67 immunofluorescence staining and flow cytometry were used to detect viability, proliferation and apoptosis in OXA-resistant cell line SW480/OXA, respectively. The expressions of Bcl-2, Bax, active caspase 3, p-Akt and pERK in SW480/OXA cells were detected with Western blot. In vivo animal study was performed finally. Results: In this study, the inhibitory effects of OXA on the proliferation and invasion of SW480/ OXA cells were significantly enhanced by Tan IIA. In addition, Tan IIA obviously enhanced the anti-apoptosis effects of OXA on SW480/OXA cells via decreasing the levels of Bcl-2, p-Akt and pERK , and increasing the levels of Bax and active caspase 3. In vivo experiments confirmed that Tan IIA enhanced OXA sensitivity in SW480/OXA xenograft model. Conclusion: We found that Tan IIA could reverse OXA resistance in OXA-resistance CRC cells. Therefore, OXA combined with Tan IIA might be considered as a therapeutic approach for the treatment of OXA-resistant CRC.

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Section: Dovepressmentioning

confidence: 98%

<p>Tanshinone IIA Reverses Oxaliplatin Resistance In Human Colorectal Cancer Via Inhibition Of ERK/Akt Signaling Pathway</p>

Zhang¹,

Ge²,

Xiang³

et al. 2019

OTT

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“…Nonetheless, the most effective treatment for patients with the incurable condition is chemotherapy, preventing tumor invasion and metastasis [9]. Luo et al (2010) implies that its effects are stable with overall 5-year survival ratioes ranging from 5% to 15% [10]. Despite recent advancements in treatment of GC, overall survival statistics for patients with gastric cancer continue to be poor, which implies the urgency of discovering and developing new therapeutic approaches or agents for GC.…”

Section: Introductionmentioning

confidence: 99%

Investigation of The Antiproliferative Effect of Colchicine on SNU-1 Gastric Cancer Cells

Yulak

2023

Cumhuriyet Science Journal

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In this study, colchicine's cytotoxic effects on SNU-1 cells were examined, and a probable mechanism behind its cytotoxicity was revealed. According to the results of the study, colchicine displayed considerable cytotoxicity with an IC50 value of 14.81ng/ml when it was administered to the cells for 24 hours at different doses ranging from 5 to 100ng/ml. Furthermore, according to mechanistic studies, usege of colchicine significantly increased both early and late apoptotic cells in flow cytometry experiments. The late apoptotic cell population percentage in the control group (5.14 ± 1.27%) dramatically increased to 22.83 ± 1.38% in 14.81ng/ml colchicine treated cells. The early apoptotic cell population percentage in the control group (2.00 ± 1.12%) increased to 6.57 ± 2.35% in 14.81ng/ml colchicine treated cells. ELISA method was used to evaluate how colchicine affects the expression of pro- and anti-apoptotic proteins in SNU-1 cells. Colchicine treatment increased pro-apoptotic Bax and cleaved caspase 3 activities, while anti-apoptotic BCL-2 levels decreased. It is concluded that colchicine increases apoptosis in SNU-1 cells, which leads to an overall increase in cell death. Colchicine's promise as an anticancer drug to treat stomach cancer, however, needs additional research to be determined.

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The relation of EGFR expression by immunohistochemical staining and clinical response of combination treatment of nimotuzumab and chemotherapy in esophageal squamous cell carcinoma

Jia¹,

Cui²,

et al. 2015

Clin Transl Oncol

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Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines

Cited by 13 publications

References 30 publications

<p>Tanshinone IIA Reverses Oxaliplatin Resistance In Human Colorectal Cancer Via Inhibition Of ERK/Akt Signaling Pathway</p>

<p>Tanshinone IIA Reverses Oxaliplatin Resistance In Human Colorectal Cancer Via Inhibition Of ERK/Akt Signaling Pathway</p>

Investigation of The Antiproliferative Effect of Colchicine on SNU-1 Gastric Cancer Cells

The relation of EGFR expression by immunohistochemical staining and clinical response of combination treatment of nimotuzumab and chemotherapy in esophageal squamous cell carcinoma

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