Cetyl Trimethyl Ammonium Bromide Modified Montmorillonite‐Doped Tasar Silk Fibroin/Polyvinyl Alcohol Blend 3D Nanowebs for Tissue Engineering Applications

Abstract

Cetyl trimethyl ammonium bromide (CTAB) modified montmorillonite (MMT) clay (CTAB-MT) doped, tasar silk fibroin-polyvinyl alcohol blend-based 3D nanowebs are generated through electrospinning technique. The morphological analysis reveals the formation of interlinked 3D nanoweb-like architecture and high surface roughness through scanning electron microscopy (SEM) and atomic force microscopy, respectively. The existence of CTAB-MT in nanowebs is confirmed by Fourier transform infrared and complete exfoliation of clay in the polymer blend matrix along with the altered crystallinity of samples is indicated in X-ray diffraction. The incorporation of CTAB-MT clay has shown the enhancement of thermal and mechanical properties of nanoweb samples while the water uptake capacity is reduced and enzymatic biodegradability is found to slow down. The samples present excellent biocompatibility with no cytotoxicity in the Alamar blue assay and high attachment as well as spreading of L929 fibroblast cells covering the entire surface as observed in SEM. The CTAB-MT clay has imparted the samples with good antimicrobial activity against E. coli and S. aureus bacterial strains. The aforementioned properties of these CTAB-MT clay doped 3D nanowebs direct toward their suitability as a potential candidate for tissue engineering applications in the biomedical field.

Preparation and Antibacterial Properties of PLA-Based Composite Nanofiber Membrane Material Loaded with Cationic Antibacterial Agent by Electrospinning

“…Whether it is CA/5-Cl8Q or CA, PEG/5-Cl8Q, from a qualitative point of view, their antibacterial activity is not as good as PLA/CTAB/5-Cl8Q. CTAB-MT clay-doped 3D nanowebs [22] showed excellent antimicrobial activity of 97.96% and 90.48% against E. coli and S. aureus bacteria, respectively. Resistance of the PLA/CTAB/5-Cl8Q to E. coli is comparable to the CTAB-MT clay-doped 3D nanowebs.…”

“…The CA/5-Cl8Q and the CA, PEG/5-Cl8Q prepared b Spasova et al [29] showed good antimicrobial activities whose measured zones of inhib tion were 4.0 ± 0.18 and 4.5 ± 0.2 cm against S. aureus and around 4.0 ± 0.15 and 4.1 ± 0.2 cm against E. coli, respectively. Whether it is CA/5-Cl8Q or CA, PEG/5-Cl8Q, from a qua itative point of view, their antibacterial activity is not as good as PLA/CTAB/5-Cl8Q CTAB-MT clay-doped 3D nanowebs [22] showed excellent antimicrobial activity 97.96% and 90.48% against E. coli and S. aureus bacteria, respectively. Resistance of th PLA/CTAB/5-Cl8Q to E. coli is comparable to the CTAB-MT clay-doped 3D nanoweb However, the Resistance of the PLA/CTAB/5-Cl8Q to S. aureus is higher than the CTA MT clay-doped 3D nanowebs.…”

“…The fibers with azole salt groups exhibited excellent antibacterial activity. Batra et al [22] fabricated hexadecyl trimethyl ammonium Bromide (CTAB) modified montmorillonite (MMT) clay (CTAB-MT) doped 3D nanowebs with good antimicrobial activity against E. coli and S. aureus bacterial strains. Nachev et al [23] successfully prepared PLLA/5-Cl8Q by electrospinning based on a biodegradable polymer containing chemical fungicides with antifungal activity.…”

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

“…Polymer, accompanied with lipid and other biocompatible materials, are always updating the drug delivery carriers for a better therapeutic effect, which are mainly promoted by advanced engineering techniques. [1][2][3][4][5][6][7][8] Today, nano techniques are frequently introduced into drug delivery fields for not only renewing the drug delivery systems, [9][10][11][12][13] but also resolving the most difficult pharmaceutical challenges. [14][15][16][17][18] Among them, the dissolution DOI: 10.1002/mame.202300361 of poorly water-soluble drugs and their related controlled release profiles are drawing increasing attention.…”