Cetylpyridinium chloride chitosan blended mucoadhesive buccal films for treatment of pediatric oral diseases

Abouhussein, Dalia M N; Nabarawi, Mohamed A. El; Shalaby, Samia; El-Bary, A. Abd

doi:10.1016/j.jddst.2020.101676

Cited by 40 publications

(23 citation statements)

References 29 publications

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“…This could be credited to the presence of plasticizer (glycerol) in oral films [ 36 , 38 ]. The tensile strength of developed-OSFs was almost matched with tensile strength of buccal films prepared by Dalia Abouhussein et al [ 58 ]. The higher tensile strength of films was due to appropriate proportion of HPMC and glycerol in the sublingual films.…”

Section: Discussionsupporting

confidence: 63%

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Poloxamer-188 and d-α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral Bioavailability of Ebastine; In Vitro and In Vivo Characterization

et al. 2021

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Orodispersible sublingual films (OSFs) composed of hydrophilic polymers were loaded with poloxamer-188 and d-α-tocopheryl polyethylene glycol succinate (TPGS-1000) mixed micelles to improve the oral bioavailability of a poorly soluble drug, ebastine (EBT). Mixed micelles formed by thin-film hydration method were incorporated into orodispersible sublingual film, consisting of HPMC and glycerol, using solvent casting technique. The mixed micelles and films were thoroughly evaluated for physicochemical characterization (size, polydispersity index, zeta potential, entrapment efficiency, thickness, weight, surface pH studies, disintegration time, swelling indices, mechanical properties, FTIR, PXRD, DSC, SEM, AFM, in vitro drug release, in vivo bioavailability, and toxicological studies). The results showed that the average particle size of mixed micelles was 73 nm. The mean zeta potential and PDI of the optimal mixed micelles formulation were −26 mV and 0.16, respectively. Furthermore, the maximum entrapment efficiency 82% was attained. The film’s disintegration time was in the range of 28 to 102 s in aqueous media. The integrity of micelles was not affected upon incorporation in films. Importantly, the micelles-loaded films revealed rapid absorption, high permeability, and increased bioavailability of EBT as compared to the pure drug. The existence of ebastine loaded mixed micelles in the films enhanced the bioavailability about 2.18 folds as compared to pure drug. Further, the results evidently established in-vitro and in-vivo performance of bioavailability enhancement, biocompatibility, and good safety profile of micelles-loaded orodispersible EBT films. Finally, it was concluded that film loaded with poloxamer-188/TPGS-1000 mixed micelles could be an effective carrier system for enhancing the bioavailability of ebastine.

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Section: Discussionsupporting

confidence: 63%

“…The HPMC usually shows swelling about 10 to 12% in aqueous media [ 57 ]. The presence of superdisintegrant (crospovidone) might be the reason of higher swelling of FC-5 [ 57 , 58 , 59 ]. The folding endurance was achieved equitably high with HPMC.…”

Section: Discussionmentioning

confidence: 99%

Poloxamer-188 and d-α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral Bioavailability of Ebastine; In Vitro and In Vivo Characterization

et al. 2021

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“… 173 Abouhussein et al explored different cetylpyridinium chloride (CPC)-chitosan-based blends comprising of methylcellulose (MC), hydroxyethylcellulose (HEC), hydroxypropyl methylcellulose (HPMC) or poly(vinyl alcohol) (PVA) for the treatment of buccal mucosa for oral-based diseases. 174 Similar to that of chitosan, cetylpyridinium chloride drug is also cationic and has antimicrobial activity against Gram-positive bacteria, e.g., S. mutans , at lower concentrations and against Gram-negative bacteria at higher concentration. 175 Here, the polycationic nature of chitosan results in strong electrostatic interaction and attaches to the negatively charged mucosal surface and is responsible for mucoadhesion.…”

Section: Antimicrobial Biopolymersmentioning

confidence: 99%

Antibacterial and Antiviral Functional Materials: Chemistry and Biological Activity toward Tackling COVID-19-like Pandemics

Balasubramaniam

Prateek

Ranjan

et al. 2020

ACS Pharmacol. Transl. Sci.

211

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The ongoing worldwide pandemic due to COVID-19 has created awareness toward ensuring best practices to avoid the spread of microorganisms. In this regard, the research on creating a surface which destroys or inhibits the adherence of microbial/viral entities has gained renewed interest. Although many research reports are available on the antibacterial materials or coatings, there is a relatively small amount of data available on the use of antiviral materials. However, with more research geared toward this area, new information is being added to the literature every day. The combination of antibacterial and antiviral chemical entities represents a potentially path-breaking intervention to mitigate the spread of disease-causing agents. In this review, we have surveyed antibacterial and antiviral materials of various classes such as small-molecule organics, synthetic and biodegradable polymers, silver, TiO2, and copper-derived chemicals. The surface protection mechanisms of the materials against the pathogen colonies are discussed in detail, which highlights the key differences that could determine the parameters that would govern the future development of advanced antibacterial and antiviral materials and surfaces.

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“…The same polymer generates biodegradable films in which metronidazole and levifloxacin can be loaded and ensures a slow and steady release over time [ 57 ]. Combining the antimicrobial character of CS with the ability to load drugs with an antibacterial action, films were obtained based on this polysaccharide or in combination with HPMC, MC, HEC, or PVA loaded with a cetylpyridinium active principle, which has a bactericidal activity against some Gram-positive bacteria such as Streptococcus mutans and even against some Gram-negative bacteria in higher concentrations [ 58 ]. The films with PVA showed an antimicrobial activity comparable to Cetylpyridiunium chloride, but it is preferable due to the longer residence time in the periodontal pocket that ensures a longer action on Streptococcus mutans .…”

Section: Polymer–drug Systemsmentioning

confidence: 99%

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

et al. 2021

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Periodontal diseases are worldwide health problems that negatively affect the lifestyle of many people. The long-term effect of the classical treatments, including the mechanical removal of bacterial plaque, is not effective enough, causing the scientific world to find other alternatives. Polymer–drug systems, which have different forms of presentation, chosen depending on the nature of the disease, the mode of administration, the type of polymer used, etc., have become very promising. Hydrogels, for example (in the form of films, micro-/nanoparticles, implants, inserts, etc.), contain the drug included, encapsulated, or adsorbed on the surface. Biologically active compounds can also be associated directly with the polymer chains by covalent or ionic binding (polymer–drug conjugates). Not just any polymer can be used as a support for drug combination due to the constraints imposed by the fact that the system works inside the body. Biopolymers, especially polysaccharides and their derivatives and to a lesser extent proteins, are preferred for this purpose. This paper aims to review in detail the biopolymer–drug systems that have emerged in the last decade as alternatives to the classical treatment of periodontal disease.

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Cetylpyridinium chloride chitosan blended mucoadhesive buccal films for treatment of pediatric oral diseases

Cited by 40 publications

References 29 publications

Poloxamer-188 and d-α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral Bioavailability of Ebastine; In Vitro and In Vivo Characterization

Poloxamer-188 and d-α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral Bioavailability of Ebastine; In Vitro and In Vivo Characterization

Antibacterial and Antiviral Functional Materials: Chemistry and Biological Activity toward Tackling COVID-19-like Pandemics

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

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