A slurry bubble column SBC is a vertical cylindrical column that consists of a solid and liquid slurry and a gas that is injected from the bottom. The study of gas holdup plays an important role in the scale up analysis of a SBC from the perspective of hydrodynamics. In SBCs, the volumetric solid concentration greatly affects the hydrodynamics. Solid particles concentration in the liquid phase changes the slurry physical properties namely increase the density, and the dynamic viscosity. In this paper, the impact of solid particles concentration on overall gas holdup is studied by using computational fluid dynamics (CFD) simulations for a heliumwater-alumina slurry bubble column, where helium gas is injected at 90 o C through a slurry of water liquid and alumina solid particles at 22 o C. It is assumed that the slurry inside the slurry bubble column is perfectly mixed, and the approaches used to model the slurry bubble column by CFD are 2D plane. In this paper, it was found that the overall gas holdup decreases by increasing the solid particle concentration at any specific superficial gas velocity and static liquid height. The CFD simulation results of the effect of solid particles concentration on gas holdup were compared with previous experimental results of helium-water-alumina SBCs for three different solid concentrations of 0%, 5%, and 10%. The results of the CFD simulations showed good agreement with the experimental results, which shows that the simulations correctly predicted the experimental effects of the solid concentrations on gas holdup.