The generation of noise is harmful to worker’s health and the stable operation of the system. Due to the high speed and high head of the high-speed centrifugal pump, the noise performance needs improvement. Therefore, a high-speed centrifugal pump was studied both in experiment and numerical way. The noise performance of the high-speed pump is improved by optimizing the design of the impeller and the guide vane. The blade leaning is also applied as an improvement with forming the X-shape stagger between rotor and stator. Base on the numerical simulation, the characteristic curves and unsteady characteristics of different optimized cases are predicted. The optimal case is selected as the final experimental object to verify the effectiveness. Numerical result indicated that the pressure fluctuation at blade pass frequency (BPF) and the fluctuated radial force is the main component of the original pump. The noise spectrum distribution of the original pump is concentrated near the BPF in the experiment, which means that the rotation effect of the impeller is the main reason for the noise of the pump. By improving the hydraulic design, the pressure fluctuation and the radial force in the pump can be effectively suppressed. But many factors affect the pump noise, the improvement of hydraulic design is limited.