Water drift emitted from cooling towers is objectionable for several reasons, mainly due to human health reasons. A numerical model to study the influence of psychrometric ambient conditions on cooling tower drift deposition was developed. The mathematical model presented, consisting of two coupled sets of conservation equations for the continuous and discrete phases, was incorporated in the general purpose CFD code Fluent. Both experimental plume performance and drift deposition were employed to validate the numerical results. This study shows the influence of variables like ambient dry bulb temperature, ambient absolute humidity and droplet exit temperature from cooling tower on the drift evaporation (and therefore deposition) and on the zone affected by the cooling tower. The stronger effect detected corresponds to the ambient dry bulb temperature.When a higher ambient temperature was present, deposition was lower (evaporation was therefore higher) and the zone affected by the cooling tower was smaller. The influence of the other two variables included in the study was weaker than the one corresponding to the dry bulb ambient temperature. A high level of ambient absolute humidity increased drift deposition and also the size of the zone affected by the cooling tower. Finally, a high level of droplet exit temperature decreased deposition and increased the zone affected by the cooling tower.Keywords: Cooling towers, drift, legionaries' disease, CFD, deposition.