A mechanical separation process in a de-oiling hydrocyclone is described in which disperse oil droplets are separated from a continuous water phase. This separation process is influenced by the droplet breakage and coalescence. Based on experimental data and simulation results in a stirred tank, a modified breakage model which can be applied to droplet breakage in the de-oiling hydrocyclone is developed. Then, a simulation model is developed coupling the numerical solution of the flow field in the hydrocyclone based on computational fluid dynamics with population balances. The homogenous discrete method and the inhomogeneous discrete method are applied for solving population balance model (PBM). The investigations show that the numerical results obtained by the simulation model coupled with the modified PBM using the inhomogeneous discrete method are good accordance with experimental data under high flow rate. According to this simulation model, the effect of three different inlet designs on the separation efficiency of the de-oiling hydrocyclone has been discussed. The results indicate that the separation efficiency of the de-oiling hydrocyclone can be improved with an appropriate inlet design. Downloaded by [University of California, San Diego] at 03:21 28 March 2016 2