Erosion wear is a big problem in hydraulic reaction turbines and centrifugal pumps. It not only reduces the life of the turbine but also reduces the performance and power output since it removes the material from the guide vane due to that water will not reach the impeller blade at the designed blade angle. In this research paper, a slurry pot tester has been designed and manufactured in the lab to analyze the suspension of sand particles in water at a varying concentration of sand, particle size, and terminal velocity by the Response Surface Methodology (RSM) and Computational Fluid Dynamics (CFD). The RSM determines the suspension speed of sand particles based on experimental data. The CFD simulation was conducted to study the internal flow field of the sand water mixture in the slurry pot tester. For experimentation, the particle size varies from 200 μm, 325 μm, and 450 μm, sand concentration varies from 1%, 3.5%, and 6%, and terminal velocity from 0.06046 m/s, 0.08768 m/s and 0.1149 m/s. Finally, surface plots, contour plots, and factorial plots are drawn in the RSM to find the outcomes of input variables on the suspension speed. The residual plot, Analysis of Variance (ANOVA), and Pareto chart show the accuracy of the predicted results of RSM. The regression equations generated by ANOVA give good accuracy with S, R2, and R2(adj) values 0.538384, 99.99%, and 99.98%, respectively. The CFD simulation results give a good inner picture of the slurry pot tester by plotting the graph of phase distribution, path line, and velocity field.