Fouling is the deposition of material on the heat transfer surface which reduces the film heat transfer coefficient. The impact of fouling on the heat exchanger is manifested as the reduction of thermal and hydraulic performance, in which the latter has a minor effect. This factor needs to be considered when calculating the effectiveness of the heat exchanger. During the design of heat exchangers, the fouling factor increases the required heat transfer area, which adds extra manufacturing costs. With less efficient heat exchangers, the economic cost of fouling is related to excess fuel consumption, loss of production, and maintenance or cleaning. The extra fuel consumption also damages the environment by increasing greenhouse gas production. Although much of the research work has been done on modeling and predicting fouling, it is still a poorly understood phenomenon representing the complexity of its mechanism. The common fouling mitigation action after the onset of fouling is to optimize the operating condition, e.g., increase the bulk flow velocity or decrease surface temperature. However, many quantitative and semi-empirical models have been developed to predict the fouling rate for preventive actions and optimizing cleaning schedules.