In the era of Corona Virus Disease 2019 (COVID-19), inappropriate indoor ventilation may turn out to be the culprit of microbial contamination in enclosed spaces and deteriorate the environment. To collaboratively improve the thermal comfort, air quality and virus spread control effect, it was essential to have an overall understanding of different ventilation modes. Hence, this study reviewed the latest scientific literature on indoor ventilation modes and manuals of various countries, identified characteristics of different ventilation modes and evaluated effects in different application occasions, wherefore to further propose their main limitations and solutions in the epidemic era. For thermal comfort, various non-uniform ventilation modes could decrease the floor-to-ceiling temperature difference, draft rate or PPD by 60%, 80% or 33% respectively, or increase the PMV by 45%. Unsteady ventilation modes (including intermittent ventilation and pulsating ventilation) could lower PPD values by 12%–37.8%. While for air quality and virus spread control, non-uniform ventilation modes could lower the mean age of air or contaminants concentration by 28.3%–47% or 15%–47% respectively, increase the air change efficiency, contaminant removal effectiveness or protection efficiency by 6.6%–10.4%, 22.6% or 14%–50% respectively. Unsteady ventilation mode (pulsating ventilation) could reduce the peak pollutant concentration and exposure time to undesirable concentrations by 31% and 48% respectively. Non-uniform modes and unsteady modes presented better performance in thermal comfort, air quality and virus spread control, whereas relevant performance evaluation indexes were still imperfect and the application scenarios were also limited.