Hydroxylation products (compounds 3 and 4) were major components in the liver extract. The metabolic pathway of famoxadone in chicken is presented in Fig 5. Abstract: The metabolism of cyprodinil, a novel broad-spectrum fungicide, was investigated in rats. After single oral administration of 0.5 or 100 mg kg À1 body weight, [phenyl-U-14 C]cyprodinil was rapidly eliminated, principally in the urine. The metabolite pattern in urine exhibited a signi®cant sex-related difference with respect to the major metabolite. Males and females both produced a dihydroxy metabolite, N-4-(hydroxyphenyl)-4-cyclopropyl-5hydroxy-6-methylpyrimidin-2-ylamine.Female rats conjugated this metabolite with sulfate exclusively at the 5-hydroxypyrimidinyl moiety, while males formed equal amounts of the monosulfate and a disulfate conjugate. The sex dimorphism in the conjugation reaction indicates the involvement of a sex-speci®c sulfotransferase that catalyzed the transfer of the second sulfate group.