Chaetomium globosum Cutaneous Fungal Infection Confirmed by Molecular Identification: A Case Report from Malaysia

Tap, Ratna Mohd; Sabaratnam, Parameswari; Ahmad, Nur Ashikin; Razak, Mohd Fuat Abd; Hashim, Rohaidah; Ahmad, Norazah

doi:10.1007/s11046-015-9890-5

Cited by 13 publications

(6 citation statements)

References 15 publications

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“…In the present study, the highest resistance rate (72.5%) was to ITZ, both consistent ( 2 , 21 , 22 ) and inconsistent ( 24 , 27 ) with the findings of previous studies. The findings on resistance to ITZ differ slightly from those reported in the U.S., Canada, Europe, and Latin America ( 2 , 21 , 22 ). In the latter regions, C. glabrata was reported to be most resistant to ITZ, followed by C. krusei and C. tropicalis .…”

Section: Discussionsupporting

confidence: 90%

“…Among pathogenic fungi, Candida species are most common cause of candidemia infections, with high mortality rates, and the incidence of candidemia infections has significantly increased in recent decades ( 1 , 2 ). Although C. albicans is the most frequently detected fungal species in this type of infection, non- C. albicans species ( C. glabrata , C. tropicalis , C. parapsilosis , and C. krusei ) have been increasingly detected, particularly in high-risk populations.…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of non- C. albicans species is critical because different species have different levels of resistance, either via intrinsic or acquired resistance mechanisms ( 9 ). A genetic analysis revealed fluconazole (FCZ) resistance mechanisms in 8% of C. glabrata isolates and 0.3% of C. albicans isolates ( 2 ). The resistance of C. glabrata to several antifungal drugs, limiting its medical efficacy ( 5 , 8 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Activities of Six Antifungal Drugs Against Candida glabrata Isolates: An Emerging Pathogen

Amirrajab

Badali

Didehdar

et al. 2016

Jundishapur J Microbiol

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BackgroundCandida glabrata is a pathogenic yeast with several unique biological features and associated with an increased incidence rate of candidiasis. It exhibits a great degree of variation in its pathogenicity and antifungal susceptibility.ObjectivesThe aim of the present study was to evaluate the in vitro antifungal susceptibilities of the following six antifungal drugs against clinical C. glabrata strains: amphotericin B (AmB), ketoconazole (KTZ), fluconazole (FCZ), itraconazole (ITZ), voriconazole (VCZ), and caspofungin (CASP).Materials and MethodsForty clinical C. glabrata strains were investigated using DNA sequencing. The in vitro antifungal susceptibility was determined as described in clinical laboratory standard institute (CLSI) documents (M27-A3 and M27-S4).ResultsThe sequence analysis of the isolate confirmed as C. glabrata and deposited on NCBI GenBank under the accession number no. KT763084-KT763123. The geometric mean MICs against all the tested strains were as follows, in increasing order: CASP (0.17 g/mL), VCZ (0.67 g/mL), AmB (1.1 g/mL), ITZ (1.82 g/mL), KTZ (1.85 g/mL), and FCZ (6.7 g/mL). The resistance rates of the isolates to CASP, FCZ, ITZ, VZ, KTZ, and AmB were 5%, 10%, 72.5%, 37.5%, 47.5%, and 27.5%, respectively.ConclusionsThese findings confirm that CASP, compared to the other antifungals, is the potent agent for treating candidiasis caused by C. glabrata. However, the clinical efficacy of these novel antifungals remains to be determined.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In Vitro Activities of Six Antifungal Drugs Against Candida glabrata Isolates: An Emerging Pathogen

Amirrajab

Badali

Didehdar

et al. 2016

Jundishapur J Microbiol

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“…DNA extractions, amplifications by polymerase chain reaction (PCR), PCR product purification and sequencing methods were performed as previously described [ 12 ]. The internal transcribed spacer (ITS) and the D1/D2 domain of the large subunit (LSU) in rRNA gene regions were amplified using universal primers ITS5/ITS4 [ 13 ] and NL1/NL4 [ 14 ].…”

Section: Molecular Identificationmentioning

confidence: 99%

A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient

et al. 2018

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We report a fatal case of Candida auris that was involved in mixed candidemia with Candida tropicalis, isolated from the blood of a neutropenic patient. Identification of both isolates was confirmed by amplification and sequencing of internal transcribed spacer and D1/D2 domain of large subunit in rRNA gene. Antifungal susceptibility test by E-test method revealed that C. auris was resistant to amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole and voriconazole. On the other hand, C. tropicalis was sensitive to all antifungal tested. The use of chromogenic agar as isolation media is vital in detecting mixed candidemia.

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“…They are known to be causative agent for emerging fungal infections in human being. The spectrum of disease include onychomycosis, superficial and deep mycoses, brain abscess, sinusitis and pneumonia . Here, we report Chaetomium globosum as a cause of invasive pulmonary infection in a patient with Wegener's granulomatosis and review all the Chaetomium infections reported till date.…”

Section: Introductionmentioning

confidence: 99%

Invasive pulmonary mycosis due to Chaetomium globosum with false‐positive galactomannan test: a case report and literature review

Capoor

Agarwal

Goel

et al. 2015

Mycoses

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In this case, the authors report Chaetomium globosum as a cause of invasive pulmonary infection in a patient with Wegener's granulomatosis. Fungal hyphae (KOH and Calcofluor) were seen on direct microscopy of lung biopsy sample and bronchoalveolar lavage (BAL) sample. C. globosum isolated on culture clinched the diagnosis of invasive pulmonary infection by Chaetomium spp. A positive galactomannan of serum and BAL was repeatedly seen and was utilised for follow-up and as prognostic marker in patient management. The patient was successfully treated with liposomal amphotericin B followed by voriconazole. All the Chaetomium infections reported till date since 1980 are reviewed. Chaetomium spp. with its unique ecology has a hidden clinical potential to cause invasive mould infections.

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Chaetomium globosum Cutaneous Fungal Infection Confirmed by Molecular Identification: A Case Report from Malaysia

Cited by 13 publications

References 15 publications

In Vitro Activities of Six Antifungal Drugs Against Candida glabrata Isolates: An Emerging Pathogen

In Vitro Activities of Six Antifungal Drugs Against Candida glabrata Isolates: An Emerging Pathogen

A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient

Invasive pulmonary mycosis due to Chaetomium globosum with false‐positive galactomannan test: a case report and literature review

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