Chaga mushroom-induced oxalate nephropathy

Kikuchi, Yūko; Seta, Koichi; Ogawa, Yoshihide; Takayama, Tatsuya; Nagata, Masao; Taguchi, Takashi; Yahata, Kensei

doi:10.5414/cn107655

Cited by 24 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 14,160 potentially relevant citations were identified and screened; 430 titles and abstracts were screened using the inclusion and exclusion criteria; 147 were excluded on the basis of the title and abstract review; and 283 articles were retrieved for detailed evaluation, of which 67 fulfilled the eligibility criteria, which involved 108 patients ( Figure 1 ). 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , …”

Section: Resultsmentioning

confidence: 99%

Secondary Oxalate Nephropathy: A Systematic Review

Lumlertgul

Siribamrungwong

Jaber

et al. 2018

Kidney International Reports

View full text Add to dashboard Cite

IntroductionLittle is known of the clinical outcomes of secondary oxalate nephropathy. To inform clinical practice, we performed a systematic review of case reports and case series to examine the clinical characteristics and outcomes of patients with secondary oxalate nephropathy.MethodsElectronic databases were searched for case reports and case series of individual cases or cohorts of patients with biopsy-proven oxalate nephropathy in native or transplanted kidneys from 1950 until January 2018.ResultsFifty-seven case reports and 10 case series met the inclusion criteria, totaling 108 patients. The case series were meta-analyzed. Mean age was 56.4 years old, 59% were men, and 15% were kidney transplant recipients. Fat malabsorption (88%) was the most commonly attributed cause of oxalate nephropathy, followed by excessive dietary oxalate consumption (20%). The mean baseline serum creatinine was 1.3 mg/dl and peaked at 4.6 mg/dl. Proteinuria, hematuria, and urinary crystals was reported in 69%, 32%, and 26% of patients, respectively. Mean 24-hour urinary oxalate excretion was 85.4 mg/d. In addition to universal oxalate crystal deposition in tubules and/or interstitium, kidney biopsy findings included acute tubular injury (71%), tubular damage and atrophy (69%), and interstitial mononuclear cell infiltration (72%); 55% of patients required dialysis. None had complete recovery, 42% had partial recovery, and 58% remained dialysis-dependent. Thirty-three percent of patients died.ConclusionSecondary oxalate nephropathy is a rare but potentially devastating condition. Renal replacement therapy is required in >50% of patients, and most patients remain dialysis-dependent. Studies are needed for effective preventive and treatment strategies in high-risk patients with hyperoxaluria-enabling conditions.

show abstract

Section: Resultsmentioning

confidence: 99%

Secondary Oxalate Nephropathy: A Systematic Review

Lumlertgul

Siribamrungwong

Jaber

et al. 2018

Kidney International Reports

View full text Add to dashboard Cite

show abstract

“…Until now only one case of Chaga mushroom-induced oxalate nephropathy was reported in Japan. 1 We here report the second case worldwide and discussed Chaga mushroom-induced oxalate nephropathy as a risk factor of chronic kidney disease.…”

Section: Disclosurementioning

confidence: 78%

“…Online search with key words "Chaga mushroom and oxalate" on PubMed shows only one report which describes a case of ESRD after ingestion of Chaga mushroom in 2014. 1 Five years later, we report the second case of Chaga mushroom-induced oxalate nephropathy worldwide. Two cases are Asian (Japan and Korea) with intractable diseases (hepatocellular carcinoma or atopic dermatitis).…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Development of End Stage Renal Disease after Long-Term Ingestion of Chaga Mushroom: Case Report and Review of Literatures

Lee

Park

et al. 2020

J Korean Med Sci

View full text Add to dashboard Cite

Chaga mushrooms are widely used in folk remedies and in alternative medicine. Contrary to many beneficial effects, its adverse effect is rarely reported. We here report a case of endstage renal disease after long-term taking Chaga mushroom. A 49-year-old Korean man with end stage renal disease (ESRD) was transferred to our hospital. Review of kidney biopsy finding was consistent with chronic tubulointerstitial nephritis with oxalate crystal deposits and drug history revealed long-term exposure to Chaga mushroom powder due to intractable atopic dermatitis. We suspected the association between Chaga mushroom and oxalate nephropathy, and measured the oxalate content of remained Chaga mushroom. The Chaga mushroom had extremely high oxalate content (14.2/100 g). Estimated daily oxalate intake of our case was 2 times for four years and 5 times for one year higher than that of usual diet. Chaga mushroom is a potential risk factor of chronic kidney disease considering high oxalate content. Nephrologist should consider oxalate nephropathy in ESRD patients exposed to Chaga mushrooms.

show abstract

“…The former includes primary hyperoxaluria which is a group of autosomal recessively inherited enzyme deficiencies that lead to the increased urinary excretion of oxalate or secondary hyperoxaluria due to ingestion of oxalate precursors—excessive vitamin C, ethylene glycol ingestion and vitamin B 6 deficiency 1 2. The latter is associated with increased dietary oxalate intake (ingestion of rhubarb, chug mushroom, starfruit), increased oxalate availability due to fat malabsorption (chronic pancreatitis, Crohn’s disease, celiac sprue and bariatric surgery) or reduction in oxalate degrading bacteria and, increased colonic permeability such as in inflammatory bowel diseases 3–6. Acute oxalate nephropathy has been associated with chronic diarrheal illness, and only one case has been reported due to acute diarrhea secondary to Clostridium difficile colitis 7.…”

Section: Introductionmentioning

confidence: 99%

Acute oxalate nephropathy associated withClostridiumdifficileinfection

et al. 2019

View full text Add to dashboard Cite

Acute oxalate nephropathy has been associated with chronic diarrheal illness and only one case has been reported due to acute diarrhea secondary to Clostridium difficile colitis. To the best of our knowledge, this is the second case report of acute oxalate nephropathy due to C.difficile colitis. A 75-year-old man with a medical history of hypertension, type 2 diabetes mellitus, chronic kidney disease stage IV, recent C.difficile colitis was admitted for acute kidney injury with a creatinine (Cr) of 8.54 mg/dL (baseline Cr, 2.3–2.6 mg/dL). His urinalysis did not show any eosinophils, casts or crystals. Antinuclear antibody, antineutrophil cytoplasmic antibody, complement levels (C3 and C4) and hepatitis screen were negative; a renal ultrasound visualized no hydronephrosis. A kidney biopsy showed widespread tubular oxalate crystal deposition suggestive of hyperoxaluria as the cause of acute kidney injury. In conclusion, an acute diarrheal illness like C.difficile colitis can cause acute oxalate nephropathy.

show abstract

Chaga mushroom-induced oxalate nephropathy

Cited by 24 publications

References 0 publications

Secondary Oxalate Nephropathy: A Systematic Review

Secondary Oxalate Nephropathy: A Systematic Review

Development of End Stage Renal Disease after Long-Term Ingestion of Chaga Mushroom: Case Report and Review of Literatures

Acute oxalate nephropathy associated withClostridiumdifficileinfection

Contact Info

Product

Resources

About