Chagas disease-associated kidney injury – A review

Silva, Geraldo Bezerra da; Antunes, Verônica Verleine Hörbe; Motta, Mariana Ferreira Benessiuti; Barros, Elvino José Guardão; Daher, Elizabeth De Francesco

doi:10.1016/j.nefrol.2016.12.001

Cited by 11 publications

(7 citation statements)

References 24 publications

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“…In advanced stages of the disease, it is possible to find a cardiac apical aneurism, pathognomonic of CCC [49]. Studies carried out in patients and postmortem analysis have demonstrated the presence of intracavitary thrombi accompanied by infarcts in several organs such as the lungs, kidneys, and brain [63][64][65].…”

Section: Chagasic Chronic Cardiomyopathymentioning

confidence: 99%

Modulation of Host Cell Apoptosis byTrypanosoma cruzi: Repercussions in the Development of Chronic Chagasic Cardiomyopathy

Román-Carraro¹,

Coria-Paredes²,

Wilkins‐Rodríguez³

et al. 2022

Chagas Disease - From Cellular and Molecular Aspects of Trypanosoma Cruzi-Host Interactions to the Clinical Intervention

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Trypanosoma cruzi is an intracellular parasite, which causes Chagas disease, affecting millions of people throughout the world. T. cruzi can invade several cell types, among which macrophages and cardiomyocytes stand out. Chagas disease goes through two stages: acute and chronic. If it becomes chronic, its most severe form is the chagasic chronic cardiomyopathy, which accounts for most of the fatalities due to this disease. For parasites to persist for long enough in cells, they should evade several host immune responses, one of these being apoptosis. Apoptosis is a type of programmed cell death described as a well-ordered and silent collection of steps that inevitably lead cells to a noninflammatory death. Cells respond to infection by initiating their own death to combat the infection. As a result, several intracellular microorganisms have developed different strategies to overcome host cell apoptosis and persist inside cells. It has been shown that T. cruzi has the ability to inhibit host cells apoptosis and can also induce apoptosis of cells that combat the parasite such as cytotoxic T cells. The aim of this chapter is to present up-to-date information about the molecules and mechanisms engaged by T. cruzi to achieve this goal and how the modulation of apoptosis by T. cruzi reflects in the development of chronic chagasic cardiomyopathy.

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Section: Chagasic Chronic Cardiomyopathymentioning

confidence: 99%

Modulation of Host Cell Apoptosis byTrypanosoma cruzi: Repercussions in the Development of Chronic Chagasic Cardiomyopathy

Román-Carraro¹,

Coria-Paredes²,

Wilkins‐Rodríguez³

et al. 2022

Chagas Disease - From Cellular and Molecular Aspects of Trypanosoma Cruzi-Host Interactions to the Clinical Intervention

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“…The infection can also occur through the ingestion of the infected insects (contaminated food), blood transfusion, organ donation, or vertical transmission [3]. Kidney involvement in Chagas disease is seldom described and rarely studied [4].…”

Section: Chagas Diseasementioning

confidence: 99%

“…Clinical manifestations of Chagas disease can be divided into acute and chronic phase [3,4]. The acute phase manifests with fever, signs of inflammation at the inoculation site, unilateral palpebral edema (Romaña sign), lymphadenopathy, and hepatosplenomegaly [3].…”

Section: Chagas Diseasementioning

confidence: 99%

“…T. cruzi has the ability to act as a parasite to a great variety of cells, including kidney cells [4]. There is evidence of functional and structural kidney abnormalities after T. cruzi infection, associated with reduction in renal blood flow, proximal tubular damage, and inflammatory interstitial infiltrate.…”

Section: Chagas Diseasementioning

confidence: 99%

“…There are reports that in the chronic phase of the disease, glomerular deposits of IgM occur at early stages, with intense inflammatory response, resulting in immune complex formation, which leads to glomerulonephritis [9]. The exact mechanism by which T. cruzi causes kidney disease is still to be elucidated [4].…”

Section: Chagas Diseasementioning

confidence: 99%

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Neglected Tropical Diseases with an Impact on Kidney Function

Silva¹,

Jereissati²,

Neri³

et al. 2018

Current Topics in Tropical Emerging Diseases and Travel Medicine

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Neglected tropical diseases are a group of infectious diseases caused by infectious and parasitic agents that occur in a large part of the world affecting millions of people and can complicate matters with serious organ damage. The kidneys can be affected in many of these diseases, including Chagas disease, dengue, leishmaniasis, leprosy, and schistosomiasis. In this chapter, we describe the mechanisms by which the kidneys are damaged in the setting of these diseases, the clinical manifestations, and the current available treatment options. We also describe the recent novel biomarkers that are under investigation for the early diagnosis of kidney injury in the course of these diseases and the future perspectives.

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