2020
DOI: 10.1016/j.bbadis.2019.165658
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Chagas disease vaccine design: the search for an efficient Trypanosoma cruzi immune-mediated control

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Cited by 59 publications
(79 citation statements)
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“…A therapeutic vaccine for Chagas disease may improve or even replace the treatment with current drugs which have several side effects and require long-term use that frequently leads to therapeutic withdrawal. The oral therapeutic vaccine SChg+SCz would also be an interesting weapon in combined therapies with parasiticidal drugs, as have been successfully reported in different pathologies ( 59 , 60 ) and reviewed by Bivona ( 22 ). With the active replication of the parasite during the acute T. cruzi infection being kept in mind, it would be interesting to evaluate if combined therapy administered during the acute phase of the infection could have a synergism with the host immune response and the drug activity to achieve parasite clearance.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…A therapeutic vaccine for Chagas disease may improve or even replace the treatment with current drugs which have several side effects and require long-term use that frequently leads to therapeutic withdrawal. The oral therapeutic vaccine SChg+SCz would also be an interesting weapon in combined therapies with parasiticidal drugs, as have been successfully reported in different pathologies ( 59 , 60 ) and reviewed by Bivona ( 22 ). With the active replication of the parasite during the acute T. cruzi infection being kept in mind, it would be interesting to evaluate if combined therapy administered during the acute phase of the infection could have a synergism with the host immune response and the drug activity to achieve parasite clearance.…”
Section: Discussionmentioning
confidence: 99%
“…In the last few years, a better understanding of the protective immune responses that can effectively arrest T. cruzi survival in mammalian host provides the fundamentals for a rational design of a prophylactic and therapeutic vaccine against Chagas disease ( 22 ). Anti- T. cruzi strategies had been focused on targeting specific metabolic biochemical pathways or parasite-specific enzymes, as well as noninvasive immunization routes ( 23 , 24 ).…”
Section: Discussionmentioning
confidence: 99%
“…Together with adjuvant E6020, Tc24 showed that 60% of therapeutically vaccinated mice had undetectable levels of parasite and decreased cardiac fibrosis. Greater efficiency was also observed in the therapeutic vaccine TG2/TcG4 in infected animals that overexpressed glutathione peroxidase and that were able to control oxidative damage responses 20,22,24 .…”
Section: Vaccine Development Against Trypanosoma Cruzi and Chagas Dismentioning
confidence: 95%
“…Chagas disease, is a zoonotic and chronic parasitic illness affecting 7-8 million people worldwide, that may be symptomatic in about 30% of those infected, leading to incapacitating situations in some of them. The disease is currently endemic in 21 Latin-American countries and, due to migration of chronically infected individuals, is now a global concern (16). Its causal agent, the flagellated protozoan T. cruzi, is an obligatory intracellular infectious agent transmitted by triatomine vectors, but also by congenital route, blood transfusions, organ transplantation or by ingesting contaminated food and beverages (17).…”
Section: Trypanosoma Cruzi Evades the Complement System: The Role Of mentioning
confidence: 99%