Chaihu and Longgu Muli Decoction demonstrate neuroprotective effects in the rat model of Parkinson's disease with depression by regulating the AMPK/mTOR signaling pathway

Liu, Wei; Cao, Junling; Ouyang, Jingping; Yin, Mengxia; Cui, Tuotuo; Liu, Xin; Li, Yujuan; Huang, Ying; Jing, Zhiwei

doi:10.1016/j.phyplu.2023.100428

Phytomedicine Plus

2023

DOI: 10.1016/j.phyplu.2023.100428

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Chaihu and Longgu Muli Decoction demonstrate neuroprotective effects in the rat model of Parkinson's disease with depression by regulating the AMPK/mTOR signaling pathway

Wei Liu¹,

Junling Cao²,

Jingping Ouyang³

et al.

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2024

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Animal models for antidepressant activity assay on natural and conventional agents: A review of preclinical testing

Kristiyani,

Ikawati,

Gani

et al. 2024

J Herbmed Pharmacol

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Depression is characterized by symptoms such as insomnia, change in appetite and body weight, impaired concentration, lethargy, agitation, psychomotor retardation, anhedonia, feelings of worthlessness, and suicidal thoughts. Various methods have been applied to assess the efficacy of antidepressants and associated molecular processes. However, guidance on the selection of methods for antidepressant testing is still lacking. This article provides a comprehensive review focusing on animal models of depression and the behavioral and molecular changes. A literature search was conducted on platforms, such as PubMed, Google Scholar, Scopus, and Science Direct to find relevant articles. This review found that chronic unpredictable mild stress might be the best and most commonly used model for inducing depression and simulating human depressive states in animals. This model employs a naturalistic approach to expose animals to unpredictable stressors that disrupt homeostasis and cause somatic, physiological, neurobiological, and biochemical disorders and behaviors. The forced swim test (FST) is the most frequently used simple behavioral testing method that is consistent with antidepressant effects, reduces immobility time, and serves as the leading indicator of antidepressant effectiveness. The most commonly observed molecular changes are those related to the levels of monoamine neurotransmitters, such as 5-hydroxytryptamine, dopamine, norepinephrine, and brain-derived neurotrophic factor (BDNF), which are the main etiological contributors to depression. The findings from this review will contribute to ongoing efforts to discover and develop drug candidates for the treatment of depression.

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Animal models for antidepressant activity assay on natural and conventional agents: A review of preclinical testing

Kristiyani,

Ikawati,

Gani

et al. 2024

J Herbmed Pharmacol

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Chaihu and Longgu Muli Decoction demonstrate neuroprotective effects in the rat model of Parkinson's disease with depression by regulating the AMPK/mTOR signaling pathway

Cited by 1 publication

References 34 publications

Animal models for antidepressant activity assay on natural and conventional agents: A review of preclinical testing

Animal models for antidepressant activity assay on natural and conventional agents: A review of preclinical testing

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