Chaihu Guizhi Ganjiang Decoction attenuates nonalcoholic steatohepatitis by enhancing intestinal barrier integrity and ameliorating PPARα mediated lipotoxicity

Wu, Hao; Lou, Tianyu; Pan, Mingxia; Wei, Zuying; Yang, Xiaoqin; Liu, Lirong; Feng, Menghan; Shi, Lixia; Qu, Biqiong; Cong, Shiyu; Chen, Kui; Yang, Haolan; Liu, Jie; Li, Yueting; Jia, Zhixin; Xiao, Hongbin

doi:10.1016/j.jep.2024.117841

Journal of Ethnopharmacology

2024

DOI: 10.1016/j.jep.2024.117841

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Chaihu Guizhi Ganjiang Decoction attenuates nonalcoholic steatohepatitis by enhancing intestinal barrier integrity and ameliorating PPARα mediated lipotoxicity

Hao Wu,

Tianyu Lou,

Mingxia Pan

et al.

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Cited by 3 publications

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Integrative transcriptomics and lipidomics unravels the amelioration effects of Radix Bupleuri on non-alcoholic fatty liver disease

Wang,

Qin,

Bai

et al. 2025

Journal of Ethnopharmacology

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Integrative transcriptomics and lipidomics unravels the amelioration effects of Radix Bupleuri on non-alcoholic fatty liver disease

Wang,

Qin,

Bai

et al. 2025

Journal of Ethnopharmacology

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Multi-omics reveals the effects of dietary supplementation with Bupleuri radix branch powder on gut microbiota and lipid metabolism: insights into gut microbial-muscle interactions

Li,

Pan,

Wang

et al. 2024

Microbiol Spectr

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Improving livestock growth and raising the quality of livestock products have attracted much attention owing to the market’s growing need for livestock products. Bupleuri Radix branches powder (BR) has a variety of health characteristics, but its effects on ruminant growth and animal product quality are still uncertain. This study explored the effects of BR on growth performance, health status, gut microbiota, and muscle lipid metabolism of Shaanxi fine-wool sheep (SFS), and examined the interaction between gut microbiota and lipid metabolism through correlation analysis. The results indicated that BR can regulate the immune function, intestinal VFAs, and enzyme activity of FSF by improving the gut microbiota, thereby affecting its muscle lipid metabolism. The lipid metabolite TG showed a strong positive correlation with the gut microbes Bacteroides and Fibrobacter , while Phosphatidylethanolamine and Phosphatidyl serine (PE and PS) showed a significant negative correlation with Fibrobacter . The above results indicate that gut microbiota and lipid metabolites interact with each other. BR has the effects of promoting SFS growth, improving body health, and improving meat quality. These findings offer new insights into improve animal growth performance and livestock product quality in modern farming. IMPORTANCE Enhancing livestock growth performance and improving meat quality are important guidelines for the development of the current animal husbandry industry; thus, we explored a comprehensive study of Bupleuri Radix (BR) on growth performance, gut microbiology, and muscle lipid metabolism in Shaanxi fine-wool sheep (SFS). Our research has found that BR could improve the growth performance of SFS and meat quality by affecting gut microbes. This study provides new solutions to improve the economic efficiency of animal husbandry.

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Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond

Tai,

Shao,

Zheng

et al. 2024

Front. Pharmacol.

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IntroductionMetabolic dysfunction-associated steatotic liver disease (MASLD) frequently confers an increased risk of vascular thrombosis; however, the marketed antiplatelet drugs are investigated for the prevention and treatment of MASLD in patients with these coexisting diseases.MethodsTo determine whether clopidogrel could ameliorate high-fat diet (HFD)-induced hepatic steatosis in mice and how it works, mice were fed on normal diet or HFD alone or in combination with or without clopidogrel for 14 weeks, and primary mouse hepatocytes were treated with palmitate/oleate alone or in combination with the compounds examined for 24 h. Body weight, liver weight, insulin resistance, triglyceride and total cholesterol content in serum and liver, histological morphology, transcriptomic analysis of mouse liver, and multiple key MASLD-associated genes and proteins were measured, respectively.Results and discussionClopidogrel mitigated HFD-induced hepatic steatosis (as measured with oil red O staining and triglyceride kit assay) and reduced elevations in serum aminotransferases, liver weight, and the ratio of liver to body weight. Clopidogrel downregulated the expression of multiple critical lipogenic (Acaca/Acacb, Fasn, Scd1, Elovl6, Mogat1, Pparg, Cd36, and Fabp4), profibrotic (Col1a1, Col1a2, Col3a1, Col4a1, Acta2, and Mmp2), and proinflammatory (Ccl2, Cxcl2, Cxcl10, Il1a, Tlr4, and Nlrp3) genes, and enhanced phosphorylation of AMPK and ACC. However, compound C (an AMPK inhibitor) reversed enhanced phosphorylation of AMPK and ACC in clopidogrel-treated primary mouse hepatocytes and alleviated accumulation of intracellular lipids. We concluded that clopidogrel may prevent and/or reverse HFD-induced hepatic steatosis in mice, suggesting that clopidogrel could be repurposed to fight fatty liver in patients.

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Chaihu Guizhi Ganjiang Decoction attenuates nonalcoholic steatohepatitis by enhancing intestinal barrier integrity and ameliorating PPARα mediated lipotoxicity

Cited by 3 publications

References 54 publications

Integrative transcriptomics and lipidomics unravels the amelioration effects of Radix Bupleuri on non-alcoholic fatty liver disease

Integrative transcriptomics and lipidomics unravels the amelioration effects of Radix Bupleuri on non-alcoholic fatty liver disease

Multi-omics reveals the effects of dietary supplementation with Bupleuri radix branch powder on gut microbiota and lipid metabolism: insights into gut microbial-muscle interactions

Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond

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