Chaihu Shugan San promotes gastric motility in rats with functional dyspepsia by regulating Drp-1-mediated ICC mitophagy

Qi Lang formula relieves constipation via targeting SCF/c-kit signaling pathway: An integrated study of network pharmacology and experimental validation

“…ICC mediates nerve and smooth muscle cells and regulates the transmission of neuromuscular signals, thereby controlling the contraction and peristalsis of the corresponding digestive tract smooth muscle [ 30 ]. Abnormalities in the number and structure of ICCs are associated with some gastrointestinal motility disorders [ 29 ], such as functional dyspepsia (FD) [ 31 ], intestinal obstruction [ 32 ], Hirschsprung disease (HSCR) and constipation [ 33 , 34 ]. The SCF/c-Kit signaling pathway is crucial for the normal development, maturation, and survival of ICCs.…”

Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases

“…In addition, Drp-1 mediated mitophagy in ICC significantly promoted gastric motility in FD rats. Lee et al [ 51 ] also found that the traditional Chinese medicine compound Chaihu Shugan powder inhibits ICC autophagy through the PI3K/PDK1 pathway, thus playing a role in promoting GI motility. In addition, many studies have found that electroacupuncture can improve GI motility disorders by activating autophagy[ 52 - 54 ].…”