Chalazia and Rosacea

Lempert, Steven L.; Jenkins, Mark S.; Brown, Stuart I.

doi:10.1001/archopht.1979.01020020220006

Cited by 48 publications

(15 citation statements)

References 5 publications

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“…Thus, rosacea is welldefined in its center but not in its periphery. Given the typologic model, the epicenter of rosacea is occupied by a few unfortunate patients with (7) flushing, (2) less transitory erythema-cyanosis, (3) telangiectasia, (4) facial edema, (5) papules/pustules, (6) ocular lesions, (7) rhinophyma, and (8) extrafacial lesions. Most patients with rosacea have only a few of these stigmata.…”

Section: Taxonomymentioning

confidence: 99%

Rosacea

Wilkin¹

1983

Int J Dermatology

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Section: Taxonomymentioning

confidence: 99%

Rosacea

Wilkin¹

1983

Int J Dermatology

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“…Interestingly, in a study by Lempert et al. , patients undergoing surgery for chalazion were 4–5 times more likely to suffer from rosacea 8 …”

Section: Introductionmentioning

confidence: 97%

“…6,7 Interestingly, in a study by Lempert et al, patients undergoing surgery for chalazion were 4-5 times more likely to suffer from rosacea. 8 The ocular manifestations of rosacea usually involve one or more of the following symptoms and signs: foreign body sensation, burning or stinging, dryness, itching, light sensitivity, blurred vision, tearing, redness, interpalpebral conjunctival hyperemia, telangiectasias of the conjunctiva and lid margin erythema, irregularities and telangiectasias. [9][10][11] Ophthalmic complications such as blepharitis, conjunctivitis, meibohmian gland dysfunction, styes, chalazia, superficial punctate keratitis and iritis may also occur.…”

Section: Introductionmentioning

confidence: 99%

Clinical and laboratory study of ocular rosacea in northern Greece

Lazaridou¹,

Fotiadou²,

Ziakas

et al. 2011

Acad Dermatol Venereol

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“…Chalazion is one of the most common benign eyelid lesions (Al-Faky, 2012; Deprez and Uffer, 2009) frequently associated with blepharitis and acne rosacea (Lempert et al, 1979; Nemet et al, 2011). The term chalazion comes from the Greek word chalaza (hailstone) (The Online Etymology Dictionary.…”

Section: Introductionmentioning

confidence: 99%

Time-dependent degenerative transformations in the lipidome of chalazia

Wojtowicz

Butovich

McMahon

et al. 2014

Experimental Eye Research

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The aim of this prospective study was to conduct histopathologic and lipidomic analyses of chalazia, in order to evaluate time-dependent changes in the lesion. Samples of surgically excised chalazia were collected over a period of 12 months from 10 patients (mean age 41 years; range, 23–58) with clinically diagnosed chalazia, who underwent scheduled surgery. The ages of chalazia varied from 2 to 28 weeks. To confirm the clinical diagnoses, the morphology of collected tissue samples was evaluated histologically after hematoxylin and eosin staining. The lipids from individual chalazia were analyzed by high-performance liquid chromatography-mass spectrometry and compared with authentic lipid standards and with the lipids of meibum collected from normal controls. We observed gradual, lesion age-dependent transformation of the lipidome of chalazia from an almost normal meibum-like composition to a very different kind of lipidome. A rapid initial increase in the free cholesterol content was followed by a gradual replacement of extremely long chain meibomian-type lipids with a mixture of shorter-chain cholesteryl esters of the C14-C18 family, triacylglycerols, ceramides, phospholipids and sphingomyelins. In addition, a rapid disappearance of wax esters and cholesteryl esters of (1-O)-acyl-omega-hydroxy fatty acids from the lipidome of aging chalazia was observed. Our results are indicative of dramatic, time-dependent changes in the lesion that may involve cholesterol as a trigger and/or a marker of subsequent degeneration of the meibomian lipidome. We hypothesize that early inhibition of these transformations may be useful in reversing the course of the disease.

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Chalazia and Rosacea

Cited by 48 publications

References 5 publications

Rosacea

Rosacea

Clinical and laboratory study of ocular rosacea in northern Greece

Time-dependent degenerative transformations in the lipidome of chalazia

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