Chalcone Tetramers, Lophirachalcone and Alatachalcone, from<i>Lophira alata</i>as Possible Anti-tumor Promoters

Murakami, Akira; Tanaka, Shizuko; Ohigashi, Hajime; Hirota, Mitsuru; Irie, Ryozo; Takeda, Nobuhiro; Tatematsu, Akira; Koshimįzu, Koichi

doi:10.1271/bbb.56.769

Cited by 29 publications

(13 citation statements)

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“…Chalcones from Lophira alata Bank ex. Gaertn F (Ochnaceae) have been reported as being responsible for possible anti-tumor-promoting properties (Murakami et al, 1992). A variety of steroids, including friedelin, taxarone, and tannins (gallic, ellagic, and caffeic acids) have been isolated from Bridelia micrantha Benth (Euphorbiaceae) (Pegel & Rogers, 1968).…”

Section: Resultsmentioning

confidence: 99%

Antimalarial Ethnobotany:In Vitro. Antiplasmodial Activity of Seven Plants Identified in the Nigerian Middle Belt

Ajaiyeoba

Ashidi

Abiodun

et al. 2005

Pharmaceutical Biology

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Seven methanol extracts of seven plants from seven plant families were screened for antimalarial properties. The plants were identified and selected from Gboko and Kastina-Ala local government areas in the Tivland ethnobotany in the Middle Belt Zone of Nigeria. Methanol plant extracts were evaluated for in vitro antimalarial properties using the lactate dehydrogenase technique, with a multiresistant strain of Plasmodium falciparum K1. Quantification of activity was by estimation of the concentration of extracts that inhibited 50% growth of parasite (IC 50) in mg=ml. Of the seven plants screened, Erythrina senegalensis DC (Leguminosae), Pericopsis elata Harms (Papilionaceae), and Bridelia micrantha Benth (Fabaceae) had IC 50 values of 99.7, 124.8, and 158.7 mg=ml, respectively. Nauclea latifolia SM (Rubiaceae) extract exhibited the least activity in the assay with an IC 50 value of 478.9 mg=ml.

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Section: Resultsmentioning

confidence: 99%

Antimalarial Ethnobotany:In Vitro. Antiplasmodial Activity of Seven Plants Identified in the Nigerian Middle Belt

Ajaiyeoba

Ashidi

Abiodun

et al. 2005

Pharmaceutical Biology

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“…A list of potential antimalarial plants including L. alata from Nigeria has been provided by Adebayo and Krettli (2011). Tetraflavonoid isolated from methanol extract of the stem bark inhibited tumour promotion in mouse (Murakami et al, 1992). Iniagbe et al (2014) validated the neuropharmacological properties of the aqueous extract of stem bark of the plant in animal models.…”

Section: Lophira Alata Banks Ex Cf Gaertn -Ochnaceaementioning

confidence: 99%

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

Gbadamosi¹,

Erinoso²

2016

Afr. J. Pharm. Pharmacol.

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Breast cancer is the leading malignancy in the South Western Nigeria; it is second to cancer of the cervix in the northwest. In north-central, 22.41% of new cancer was registered for breast cancer in five years and accounted for 35.41% of all cancers in women. The limitations of orthodox drugs such as cost, accessibility, effectiveness, and side effects necessitate the search for cheap, safe and effective phytomedicine in cancer management. Thus, this paper reviewed twenty plants used traditionally for the management of breast cancer; this was with a view to presenting them for future research activities and scientific validation of their potency in cancer regimen.

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“…The stem bark of L. alata is rich in chalcone dimers such as lophirones B and C, tetramers, and hexaflavonoids . The stem‐bark extract of the plant possesses antibacterial effects against Sarcinia lutea and Staphylococcus aweus . Crude methanolic extract and lophirone A derived from L. alata have also been reported to suppress the antitumor promoter, Epstein‐Barr virus (EBV) .…”

Section: Introductionmentioning

confidence: 99%

Electrophilic and Reactive Oxygen Species Detoxification Potentials of Chalcone Dimers is Mediated by Redox Transcription Factor Nrf‐2

Ajiboye

Yakubu

Oladiji

2013

J Biochem & Molecular Tox

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Nuclear erythroid related factor-2 (Nrf2), a redox-transcription factor, plays a critical role in the detoxification of electrophilic and reactive oxygen species that halt various biochemical and molecular processes. This makes it a candidate for regulation by polyphenols. This study investigates the capability of chalcone dimers (lophirones B and C) to induce expressions and activities of cytoprotective enzymes. Chalcone dimers administration to rats not only induced the Nrf2, but also suppressed cytoplasmic Kelch-like ECH-associated protein 1 (Keap1) expressions. In addition, the chalcone dimers significantly (p < 0.05) increased the expressions and activities of nicotinamide adenine dinucleotide and reduced quinone oxidoreductase-1, glutathione-S-transferase, epoxide hydrolase and uridyl glucuronosyl transferase in rat liver. Also, activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in rat liver increased significantly (p < 0.05). Overall, lophirones B and C increased the expressions and activities of cytoprotective proteins in rat liver possibly through the reduction of cytoplasmic Keap1 expression, leading to the nuclear translocation of Nrf2.

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Chalcone Tetramers, Lophirachalcone and Alatachalcone, fromLophira alataas Possible Anti-tumor Promoters

Cited by 29 publications

References 0 publications

Antimalarial Ethnobotany:In Vitro. Antiplasmodial Activity of Seven Plants Identified in the Nigerian Middle Belt

Antimalarial Ethnobotany:In Vitro. Antiplasmodial Activity of Seven Plants Identified in the Nigerian Middle Belt

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

Electrophilic and Reactive Oxygen Species Detoxification Potentials of Chalcone Dimers is Mediated by Redox Transcription Factor Nrf‐2

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