Challenge confirmation of late-onset reactions to extensively hydrolyzed formulas in infants with multiple food protein intolerance

Allergy to extensively hydrolysed formulas

“…7 Most recently however, chronic manifestations have been described, in particular vomiting, diarrhoea, growth retardation and food rejection. The series presented by Hill et al, 8 and Ammar et al 9 with 6 and 25 children respectively, show several common features. A clear predominance of unspecific chronic manifestations with gastrointestinal reactions in the first place, followed by irritability, eczema and growth retardation and reversibility of symptoms with amino acid based formula are the most relevant characteristics.…”

“…The immunologic tolerance acquisition to EHF and CMP occurs later, as has been suggested by other authors. 8 In the presence of allergy to other foods, a restricted diet based on AABF is required for a longer duration. Isolated CMA usually develops in the first year of life and is considered to be transitory in most cases (tolerance in 75% of cases at age of 3 years).…”

“…Nevertheless, it is not clear for how long should AABF diet be kept. Hill et al 8 reported the use of AABF for more than 6 months in 6 infants with multiple food allergy. In a long term follow-up evaluation of 52 children with CMA and allergy to EHF, AABF was used for 11.478 months (3.5 to 41 months) and tolerance to CMP was achieved at a median age of 20.5 months.…”

Llanto excesivo en los primeros meses de vida. Revisión

“…observaron que el 44% de los lactantes estudiados mostraron un comportamiento irritable y "colicoso" durante el desafío con leche de vaca. 37 Desde entonces, múltiples ensayos clínicos han demostrado un beneficio en el tratamiento de los lactantes con cólicos, tanto con soja como con hidrolizados extensos de proteínas, incluso cuando ningún otro síntoma era evidente. 38,39 En la actualidad, no hay evidencia convincente de que otras alergias alimentarias fuera de la alergia a la leche de vaca puedan provocar llanto e irritabilidad en los primeros meses de vida.…”

Efficacy of Feeding Team Recommendations for Infants/Children Presenting With Signs of Milk Allergy

“…10 Some infants respond well to an extensively hydrolyzed formula (EHF); however, many infants require an amino acid formula before they experience relief. [11][12][13][14][15][16][17][18] EE, a condition that has become increasingly prevalent over the past 15 years, may present with symptoms suggestive of GER. However, EE does not respond to the medications used to treat GER.…”