Challenges and current evidence on the management of bladder pain syndrome

Chrysanthopoulou, Eleftheria L.; Doumouchtsis, Stergios K.

doi:10.1002/nau.22475

Cited by 23 publications

(15 citation statements)

References 111 publications

(136 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our retrograde tracing studies we focused only on male mice to avoid estrous cycles as a confounding factor in gene expression (Mónica Brauer and Smith, 2015). Since neurogenic bladder and bladder pain syndromes occur more frequently and with greater severity in women than men, sex-specific variation in gene expression may be a contributing factor to these differences (Irwin et al, 2006; Chrysanthopoulou and Doumouchtsis, 2014; Mónica Brauer and Smith, 2015). It will be of interest in subsequent studies to investigate sex differences in Htr3a gene expression patterns throughout development or into adulthood.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Expression of Serotonin Receptor 5-HT3A in Developing Sensory Innervation of the Lower Urinary Tract

Southard‐Smith

2017

Front. Neurosci.

View full text Add to dashboard Cite

Sensory afferent signaling is required for normal function of the lower urinary tract (LUT). Despite the wide prevalence of bladder dysfunction and pelvic pain syndromes, few effective treatment options are available. Serotonin receptor 5-HT3A is a known mediator of visceral afferent signaling and has been implicated in bladder function. However, basic expression patterns for this gene and others among developing bladder sensory afferents that could be used to inform regenerative efforts aimed at treating deficiencies in pelvic innervation are lacking. To gain greater insight into the molecular characteristics of bladder sensory innervation, we conducted a thorough characterization of Htr3a expression in developing and adult bladder-projecting lumbosacral dorsal root ganglia (DRG) neurons. Using a transgenic Htr3a-EGFP reporter mouse line, we identified 5-HT3A expression at 10 days post coitus (dpc) in neural crest derivatives and in 12 dpc lumbosacral DRG. Using immunohistochemical co-localization we observed Htr3a-EGFP expression in developing lumbosacral DRG that partially coincides with neuropeptides CGRP and Substance P and capsaicin receptor TRPV1. A majority of Htr3a-EGFP+ DRG neurons also express a marker of myelinated Aδ neurons, NF200. There was no co-localization of 5-HT3A with the TRPV4 receptor. We employed retrograde tracing in adult Htr3a-EGFP mice to quantify the contribution of 5-HT3A+ DRG neurons to bladder afferent innervation. We found that 5-HT3A is expressed in a substantial proportion of retrograde traced DRG neurons in both rostral (L1, L2) and caudal (L6, S1) axial levels that supply bladder innervation. Most bladder-projecting Htr3a-EGFP+ neurons that co-express CGRP, Substance P, or TRPV1 are found in L1, L2 DRG, whereas Htr3a-EGFP+, NF200+ bladder-projecting neurons are from the L6, S1 axial levels. Our findings contribute much needed information regarding the development of LUT innervation and highlight the 5-HT3A serotonin receptor as a candidate for future studies of neurally mediated bladder control.

show abstract

Section: Discussionmentioning

confidence: 99%

Dynamic Expression of Serotonin Receptor 5-HT3A in Developing Sensory Innervation of the Lower Urinary Tract

Southard‐Smith

2017

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The prevalence of IC/PBS is thought to be markedly higher (100–300/100,000 women) than in previous years 3 . Frequency, urgency and pain during bladder filling are the most commonly reported symptoms of IC/BPS 4 .…”

Section: Introductionmentioning

confidence: 88%

Contrast Enhanced Magnetic Resonance Imaging as a Diagnostic Tool to Assess Bladder Permeability and Associated Colon Cross Talk: Preclinical Studies in a Rat Model

et al. 2015

View full text Add to dashboard Cite

Purpose Interstitial cystitis/painful bladder syndrome (IC/PBS) is a devastating disease that is associated with multiple symptoms, and is usually diagnosed on the basis of pain, urgency and frequency in the absence of other known causes. To date there is no diagnostic test. Methods In vivo diagnostic contrast-enhanced magnetic resonance imaging (CE-MRI) was used, involving intravesical administration of Gd-DTPA (gadolinium diethylene triamine penta acetic acid) contrast via a catheter, for visualization of increased permeability of the bladder urothelium, and i.v. administration of Gd-DTPA was used to visualize secondary tissue effects to the colon, in a rat model undergoing intravesical exposure to protamine sulfate (PS). Results Both bladder urothelilium and colonic mucosa were assessed 24 hours following bladder PS exposure. Enhanced contrast MR images were able to establish bladder urothelium leakage of Gd-DTPA (399.7±68.7 % change in MRI signal intensity (SI) for PS-exposed rats, compared to 39.2±12.2 for controls; p<0.0001), and colonic-related uptake in contrast agent (65.2±17.1 % for PS-exposed rats, compared to 20.8±9.8 for controls; p<0.01) following bladder PS exposure. Kinetics of Gd-DTPA uptake and excretion were also obtained over 20 min in the bladder, and over 30 min in the colon, indicating increased signal intensities at 7 and 12 min, respectively. Conclusions These preliminary studies indicate that CE-MRI is capable of monitoring primary bladder urothelium loss of impermeability and secondary enhanced contrast in colon mucosa. This method can be considered a potential clinical diagnostic method for IC/PBS that involves loss of the permeability barrier, and assessing visceral organ cross-talk.

show abstract

“…[110][111][112] Comorbidity with other chronic pelvic pain disorders occurs in up to 40% of IC/PBS patients, 1,2,67,73,113 and a significant proportion of patients also suffer from fibromyalgia, allergies, and mood disorders. 34,72,[114][115][116] Like many idiopathic pain disorders, IC/PBS is polysyndromic and patients may exhibit one of multiple subtypes. Classically, IC referred to observable findings on cystoscopic examinations: namely, glomerulations, overt histopathology, or Hunner's ulcers 110,111 ; however, the patient population was far more heterogeneous than the strict criteria used by research qualifications.…”

Section: Interstitial Cystitis/painful Bladder Syndromementioning

confidence: 99%

Stress and Chronic Pelvic Pain

Pierce¹,

Christianson²

2015

Progress in Molecular Biology and Translational Science

View full text Add to dashboard Cite

Challenges and current evidence on the management of bladder pain syndrome

Abstract: Efforts are focused on different pathways for the early identification of this syndrome, trying to elucidate the pathogenetic mechanism, as well as introducing effective treatments.

Cited by 23 publications

References 111 publications

Dynamic Expression of Serotonin Receptor 5-HT3A in Developing Sensory Innervation of the Lower Urinary Tract

Dynamic Expression of Serotonin Receptor 5-HT3A in Developing Sensory Innervation of the Lower Urinary Tract

Contrast Enhanced Magnetic Resonance Imaging as a Diagnostic Tool to Assess Bladder Permeability and Associated Colon Cross Talk: Preclinical Studies in a Rat Model

Stress and Chronic Pelvic Pain

Contact Info

Product

Resources

About