Challenges and Future of the International Parkinson and Movement Disorder Society Prodromal Parkinson's Disease Criteria: Are We On the Right Track?

Kulcsarova, Kristina; Skorvanek, Matej

doi:10.1002/mds.29724

Cited by 1 publication

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“…ies when applied in enriched cohorts (e.g., [59][60][61]), although they struggle with low sensitivity in the general population if specific markers with high LR (DaTscan, polysomnography-confirmed RBD) are not included (e.g., [60,62]). As they are heavily weighted towards RBD-positive prodromal subtype, their applicability for other pPD subtypes with less extensive load of non-motor symptoms is rather limited [63].…”

Section: Levels Of Certaintymentioning

confidence: 99%

Defining Parkinson’s Disease: Past and Future

Kulcsarova,

Skorvanek,

Postuma

et al. 2024

Journal of Parkinson’s Disease

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Parkinson’s disease (PD) is the second most common still relentlessly progressive neurodegenerative disorder with a long period in which the pathophysiological process is already spreading but cardinal motor symptoms are not present. This review outlines the major developments and milestones in our understanding of PD that have shaped the way we define this disorder. Past criteria and definitions of PD have been based on clinical motor manifestations enabling diagnosis of the disease only in later symptomatic stages. Nevertheless, with advancing knowledge of disease pathophysiology and aim of early disease detection, a major shift of the diagnostic paradigm is being advocated towards a biological definition similar to other neurodegenerative disorders including Alzheimer’s disease and Huntington’s disease, with the ultimate goal of an earlier, disease course modifying therapy. We summarize the major pillars of this possible approach including in vivo detection of neuronal α-synuclein aggregation, neurodegeneration and genetics and outline their possible application in different contexts of use in the frame of biological PD definition.

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