Economic growth, social wellbeing, and infrastructure are strongly interrelated and jointly contribute to national development. Therefore, evaluation and selection of a road infrastructure project direly need a comprehensive sustainability assessment integrating holistic decision criteria. This study presents an elaborate life cycle sustainability-based project evaluation tool, comprising an assessment framework, an integration model, and a decision framework. In the first phase, a life cycle sustainability assessment (LCSA) framework for road infrastructure is established using mixed methods. In the second phase, interviews are conducted to obtain pairwise comparisons among impact categories and subjective reasoning of their priorities. Analytical hierarchy process (AHP) is adopted to develop the LCSA integration model. The minimum threshold limits of impact categories are evaluated and integrated into the proposed decision framework. Further, thematic and cross-sectional analyses are performed on the interview findings to rationalize the proposed decision framework. The findings include a detailed and customized project assessment framework, an integration model, and a decision framework for the assessment of different project alternatives. This study helps policy- and decision-makers in selecting the project alternative by maximizing sustainability in road infrastructure projects. Insights into environmental and social externalities and their quantitative interpretation throughout the life of the road are also achieved.