Challenges and opportunities to improving research in maternal cardiovascular health

Lewey, Jennifer

doi:10.1038/s44161-022-00201-x

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…This finding reaffirms previous research highlighting age-related changes including both structural changes such as increased LV wall mass 43 , possibly driven by cardiomyocyte hypertrophy and functional changes such as the decline in diastolic function 24,44 . This decline in the CV may be driven by well-established age-related cellular and tissue level remodelling including impaired sodium channel function 44 (potentially though loss-of-function genetic mutations such as SCN5A as identified in previous ECG age-delta GWAS 45 and experimental studies 46 ) and the development of myocardial fibrosis 24,47 . It may also be affected by gap junction decoupling such as connexin 43 downregulation which is a known pathological remodelling in patients with ventricular hypertrophy and ischaemic heart diseases 48 .…”

Section: Discussionmentioning

confidence: 99%

Developing Cardiac Digital Twins at Scale: Insights from Personalised Myocardial Conduction Velocity

Qian,

Ugurlu,

Fairweather

et al. 2023

Preprint

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Large-cohort studies using cardiovascular imaging and diagnostic datasets have assessed cardiac anatomy, function, and outcomes, but typically do not reveal underlying biological mechanisms. Cardiac digital twins (CDTs) provide personalized physics- and physiology-constrainedin-silicorepresentations, enabling inference of multi-scale properties tied to these mechanisms.We constructed 3464 anatomically-accurate CDTs using cardiac magnetic resonance images from UK biobank and personalised their myocardial conduction velocities (CVs) from electrocardiograms (ECG), through an automated framework.We found well-known sex-specific differences in QRS duration were fully explained by myocardial anatomy, as CV remained consistent across sexes. Conversely, significant associations of CV with ageing and increased BMI suggest myocardial tissue remodelling. Novel associations were observed with left ventricular ejection fraction and mental-health phenotypes, through a phenome-wide association study, and CV was also linked with adverse clinical outcomes.Our study highlights the utility of population-based CDTs in assessing intersubject variability and uncovering strong links with mental health.

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