Challenges and processes of selecting outcome measures for the NIMH Collaborative HIV/STD Prevention Trial

McClintock, Cindy; Hiv, Nimh Collaborative; Hartwell, Tyler; Cressman, Gordon; DeCain, Martha; Ganapathi, L.; Green, Annette; Hansen, Nellie I.; Li, Sheping; McFadden, Deborah E.; Myers, David; Parker, Corette B.; Robinson, Pauline; Smith, Donald R.; Strader, Lisa; Torres, Pablo; Woelk, Godfrey; Woodsong, Cynthia

doi:10.1097/01.aids.0000266455.03397.08

Cited by 8 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We conducted a longitudinal study of syphilis infection and reinfection among participants in the Peru site of the National Institute of Mental Health (NIMH) Collaborative HIV/STD Prevention Trial [14–16]. Briefly, participants of ethnographically-identified sub-populations at high risk for HIV acquisition were recruited from low-income barrios in three urban, coastal cities: Lima, Trujillo and Chiclayo, Peru between 2002 and 2005.…”

Section: Methodsmentioning

confidence: 99%

Risk Factors Associated with Incident Syphilis in a Cohort of High-Risk Men in Peru

Park¹,

Konda

Roberts³

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

BackgroundSyphilis is concentrated among high-risk groups, but the epidemiology of syphilis reinfection is poorly understood. We characterized factors associated with syphilis incidence, including reinfection, in a high-risk cohort in Peru.MethodsParticipants in the NIMH CPOL trial were assessed at baseline and 2 annual visits with HIV/STI testing and behavioral surveys. Participants diagnosed with syphilis also attended 4- and 9-month visits. All participants underwent syphilis testing with RPR screening and TPPA confirmation. Antibiotic treatment was provided according to CDC guidelines. Reinfection was defined as a 4-fold titer increase or recurrence of seroreactivity after successful treatment with subsequent negative RPR titers. The longitudinal analysis used a Possion generalized estimating equations model with backward selection of variables in the final model (criteria P <0.02).ResultsOf 2,709 participants, 191 (7.05%) were RPR-reactive (median 1:8, range 1:1–1:1024) with TPPA confirmation. There were 119 total cases of incident syphilis, which included both reinfection and first-time incident cases. In the bivariate analysis, the oldest 2 quartiles of age (incidence ratio (IR) 3.84; P <0.001 and IR 8.15; P <0.001) and being MSM/TW (IR 6.48; P <0.001) were associated with higher risk of incident syphilis infection. Of the sexual risk behaviors, older age of sexual debut (IR 12.53; P <0.001), not being in a stable partnership (IR 1.56, P = 0.035), higher number of sex partners (IR 3.01; P <0.001), unprotected sex in the past 3 months (IR 0.56; P = 0.003), HIV infection at baseline (IR 3.98; P <0.001) and incident HIV infection during the study period (IR 6.26; P = 0.003) were all associated with incident syphilis. In the multivariable analysis, older age group (adjusted incidence ratio (aIR) 6.18; P <0.001), men reporting having sex with a man (aIR 4.63; P <0.001), and incident HIV infection (aIR 4.48; P = 0.008) were significantly associated.ConclusionsWe report a high rate of syphilis reinfection among high-risk men who have evidence of previous syphilis infection. Our findings highlight the close relationship between HIV incidence with both incident syphilis and syphilis reinfection. Further studies on syphilis reinfection are needed to understand patterns of syphilis reinfection and new strategies beyond periodic testing of high-risk individuals based on HIV status are needed.

show abstract

Section: Methodsmentioning

confidence: 99%

Risk Factors Associated with Incident Syphilis in a Cohort of High-Risk Men in Peru

Park¹,

Konda

Roberts³

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…All interviews were recorded and transcribed verbatim, with personal identifying information removed. Observation notes, field notes, and transcribed interviews were entered into and analyzed with Atlas.ti computer software (Muhr, 1997), using thematic codes reflecting the goals and hypotheses of the project. Documents were first coded for demographic and other identifying factors such as gender, ethnicity, and the type of data gathered.…”

Section: Methodsmentioning

confidence: 99%

“…Retention of peer educators in HIV/AIDS-intervention projects and the sustainability of peer-driven HIV/AIDS interventions are of critical importance to researchers and federal funding agencies in evaluating the effectiveness of these public health initiatives to stop the spread of HIV infections (Gandelman, Desantis, & Rietmeijer, 2006; National Institute of Mental Health (NIMH) Collaborative HIV/STD Prevention Trial Group, 2007). Potential and ongoing peer HIV-prevention programs must demonstrate their efficacy by adhering to a “best practices” approach and evidence-based methods (Kalichman et al, 2007; Lyles et al, 2007).…”

mentioning

confidence: 99%

“…The focus of outcome analyses have tended to include adherence to harm-reduction practices (Latkin, Sherman, & Knowlton, 2003), increased motivation to engage in protective behaviors (Broadhead et al, 1998), a decline in risky behavior (Dickson-Gomez, Weeks, Martinez, & Convey, 2006; Hays, Rebchook, & Kegeles, 2003; Knauz et al, 2007; Williamson, Hart, Flowers, Frankis, & Der, 2001), and increased self-efficacy on the individual level (Bryan, Robbins, Ruiz, & O’Neill, 2006; Norr, Norr, McElmurry, Tlou, & Moeti, 2004), as well as increased self-efficacy in members of the peers’ social network and community (Kennedy, Rogers, & Crossley, 2007; Latkin & Knowlton, 2005; Weeks, Li, et al, 2009). Programs that can demonstrate changes in individual-level behavior are considered successful, and if successfully replicated, are often given continued support (Gandelman et al, 2006; NIMH Collaborative HIV/STD Prevention Trial Group, 2007). Thus, changes in risky behavior are often the measurement by which peer-driven, HIV-intervention programs are evaluated.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Altruism and Peer-Led HIV Prevention Targeting Heroin and Cocaine Users

et al. 2010

View full text Add to dashboard Cite

Peer-delivered HIV prevention and intervention programs play an important role in halting the spread of HIV. Rigorous scientific analysis of the forementioned programs have focused on the immediate reduction of risk-related behaviors among the target populations. In our longitudinal study of the RAP Peer Intervention for HIV, we assessed the long-term behavioral effects of a peer-led HIV intervention project with active drug users. Initial analysis of the qualitative data highlights the role of altruism as a motivator in sustaining peer educators beyond the immediate goals of the project. We contend that altruism found in volunteers is an important factor in maintaining long-term participation in HIV intervention programs and initiatives using peer educators.

show abstract

Risky Sexual Behavior and Correlates of STD Prevalence Among African American HIV Serodiscordant Couples

Wingood¹,

El‐Bassel²,

et al. 2010

AIDS Behav

View full text Add to dashboard Cite

This paper reports baseline behavioral and biological data collected from a cohort of 535 African American HIV serodiscordant couples enrolled in the Eban study across four urban metro areas. Data were collected on (1) the prevalence of risky sexual behaviors that occur within a couple and with concurrent sexual partners, (2) the STD prevalence for each member of the couple and (3) the correlates of STDs in the male partner as well as in the female partner. Presentation of the sociodemographic characterization and HIV risk behavior profiles of African American HIV serodiscordant couples represents an important initial description of a hidden, vulnerable population. Future research should be conducted with diverse samples of African American couples (i.e., younger couples, non-stable couples) to explore other potential correlates of STD prevalence.

show abstract

Challenges and processes of selecting outcome measures for the NIMH Collaborative HIV/STD Prevention Trial

Cited by 8 publications

References 30 publications

Risk Factors Associated with Incident Syphilis in a Cohort of High-Risk Men in Peru

Risk Factors Associated with Incident Syphilis in a Cohort of High-Risk Men in Peru

Altruism and Peer-Led HIV Prevention Targeting Heroin and Cocaine Users

Risky Sexual Behavior and Correlates of STD Prevalence Among African American HIV Serodiscordant Couples

Contact Info

Product

Resources

About