2021
DOI: 10.1007/7355_2021_136
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Challenges and Promises for Obtaining New Antiprotozoal Drugs: What’s Going Wrong?

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Cited by 5 publications
(7 citation statements)
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“…Protozoans are microscopic, nonfilamentous protists belonging to a multitude of phyla, with many genera and species described so far, many of which possess ecological and industrial relevance. However, they sometimes produce disease in vertebrates, which may range from mild to moderate, such as those induced by Toxoplasma gondii or Entamoeba histolytica , or may lead to more serious conditions, in the case of infections due to Cryptosporidium parvum , Giardia lamblia , Trichomonas vaginalis , Babesia spp., but also very serious and widespread ones, such as malaria, leishmaniasis, Chagas disease, and African sleeping disease 1 , 2 . Although rare, there are also several fatal protozoal diseases, mostly provoked by amoebae belonging to Naegleria fowleri, Acanthamoeba spp.…”
Section: Introductionmentioning
confidence: 99%
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“…Protozoans are microscopic, nonfilamentous protists belonging to a multitude of phyla, with many genera and species described so far, many of which possess ecological and industrial relevance. However, they sometimes produce disease in vertebrates, which may range from mild to moderate, such as those induced by Toxoplasma gondii or Entamoeba histolytica , or may lead to more serious conditions, in the case of infections due to Cryptosporidium parvum , Giardia lamblia , Trichomonas vaginalis , Babesia spp., but also very serious and widespread ones, such as malaria, leishmaniasis, Chagas disease, and African sleeping disease 1 , 2 . Although rare, there are also several fatal protozoal diseases, mostly provoked by amoebae belonging to Naegleria fowleri, Acanthamoeba spp.…”
Section: Introductionmentioning
confidence: 99%
“…Although rare, there are also several fatal protozoal diseases, mostly provoked by amoebae belonging to Naegleria fowleri, Acanthamoeba spp. and Balamuthia mandrillaris genera/species 1 . Few effective therapeutic approaches are available so far for treating most diseases provoked by protozoans 1 .…”
Section: Introductionmentioning
confidence: 99%
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