Flow-shop sequence-dependent group scheduling (FSDGS) problem has been extensively investigated in the literature also due to many manufacturers who implemented the concept of group technology to reduce set-up costs, lead times, work-in-process inventory costs, and material handling costs. On the other hand, skilled workforce assignment (SWA) to machines of a given shop floor may represent a key issue for enhancing the performance of a manufacturing system. As the body of literature addressing the group scheduling problems ignored up to now the effect of human factor on the performance of serial manufacturing systems, the present paper moves in that direction. In particular, an M-machine flow-shop group scheduling problem with sequence-dependent set-up times integrated with the worker allocation issue has been studied with reference to the makespan minimization objective. First, a Mixed Integer Linear Programming model of the proposed problem is reported. Then, a well-known benchmark arisen from the literature is adopted to carry out an extensive comparison campaign among three properly developed metaheuristics based on a genetic algorithm framework. Once the best procedure among those tested is selected, it is compared with an effective optimization procedure recently proposed in the field of FSDGS problems, being this latter properly adapted to run the SWA issue. Finally, a further analysis dealing with the trade-off between manpower cost and makespan improvement is proposed.