BackgroundDuring the COVID‐19 pandemic, acute care nurse managers functioned in a critical role by helping to advance the mission and goals of their organization while navigating a rapidly evolving healthcare landscape. This resulted in high levels of ongoing job‐related stress which is linked to negative physical, psychological, and job‐related outcomes. Little is known about the perceptions regarding their own professional well‐being during this time.AimThe aim of this study was to qualitatively describe acute care nurse managers' perceptions of and barriers to their professional well‐being.MethodsUsing a qualitative descriptive approach, nurse managers from a hospital system in the southwestern United States responded to two short‐answer, survey‐based questions in 2022: (1) “Describe the definition of nurse‐manager well‐being in your own words” and (2) “What do you feel is your biggest barrier to professional well‐being?” Reflexive thematic analysis was utilized to analyze participant responses (N = 80).ResultsProfessional well‐being is a complex concept influenced by the nurse manager's ability to navigate work–life balance; care for their own physical, emotional, and spiritual selves; give and receive support from stakeholders; and manage feelings of thriving vs. struggling in the role. Barriers most cited as influencing well‐being included having too little time to get things done coupled with increasing workloads, feeling stuck in the middle among stakeholders, and coping with ongoing staffing challenges.Linking Evidence to ActionThe definition of and barriers to well‐being are influenced by the specific needs and experiences of the nurse manager. While not all barriers can be immediately removed, the identification of individual and organization‐specific barriers needs to be taken seriously, reviewed by those who can promote change, and evidence‐based solutions for improvement piloted or implemented when feasible.