Challenges for the development of surface modified biodegradable polyester biomaterials: A chemistry perspective

Abstract

The design of current implants produced from biodegradable polyesters is based on strength and rate of degradation and tailored by the choice of polyester used. However, detailed knowledge about the degradation mechanism of surface modified materials with applications in biomaterials science and tissue engineering is currently lacking. This perspective aims to outline the need for a greater focus on analyzing the degradation of modified polyesters to ensure they can fulfil their intended function and that degradation products can effectively be cleared from the body. The status of the literature regarding surface modified polyesters is summarized to illustrate the main aspects investigated in recent studies and specifically the number of studies investigating the fate of the materials upon degradation.

Strategies for Enhancing Polyester-Based Materials for Bone Fixation Applications

“…There is a large scope of data regarding the biocompatibility of polyester materials, specifically with regards to surface enhancement [ 101 , 102 , 103 , 104 , 105 ]. As the polymer biomaterials have interaction directly with an extracellular environment, it is vital that an adverse immune response is not provoked [ 91 , 100 ]. A few important surface characteristics can be altered to obtain the right biocompatibility control for the intended application.…”

“… Polymer surface modification methods (for biodegradable polymers) [ 89 , 91 , 98 , 99 , 100 , 101 ]. …”

Surface modification of synthetic polymer fibers

“…To address this, surface modification techniques are being explored to enhance the environmental compatibility of synthetic fibers, aiming to reduce their ecological footprint and promote sustainable practices. 23 These areas are expected to be the largest drivers of innovation, as the demand for multifunctional and high-performance materials continues to grow.…”