Challenges in Diagnosis and Management of Paget’s Disease of the Breast—a Retrospective Study

Challa, Vasu Reddy; Deshmane, Vijayalakshmi

doi:10.1007/s12262-014-1167-6

Cited by 20 publications

(21 citation statements)

References 22 publications

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“…Mastectomy was the conventional treatment for patients with Paget's disease, with 80.95% of patients in the present study, similar to a previous report . BSC can be considered in patients with no presence of underlying neoplasm in the breast . There is an increasing trend in patients with Paget's disease to consider BCS; however, all efforts should be undertaken to ensure local control …”

Section: Discussionsupporting

confidence: 83%

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Present and changing trends in surgical modalities and neoadjuvant chemotherapy administration for female breast cancer in Beijing, China: A 10‐year (2006–2015) retrospective hospitalization summary report‐based study

et al. 2018

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BackgroundThis study was conducted to describe present and changing trends in surgical modalities and neoadjuvant chemotherapy (NACT) in female breast cancer patients in China from 2006 to 2015.MethodsData of 44 299 female breast cancer patients from 15 tertiary hospitals in Beijing were extracted from hospitalization summary reports. Surgeries were categorized into five modalities: breast‐conserving surgery (BCS), simple mastectomy (SM), modified radical mastectomy (MRM), radical mastectomy (RM), and extensive radical mastectomy (ERM).ResultsIn total, 38 471 (86.84%) breast cancer patients underwent surgery: 22.64% BCS, 8.22% SM, 63.97% MRM, 4.24% RM, and 0.93% ERM. Older patients (> 60) underwent surgery more frequently than younger patients (< 60). The proportion of patients who underwent BCS was highest in the age ≥ 80 (39.24%) and < 40 (28.69%) subgroups and in patients with papillary carcinoma (35.48%), and lowest in the age 60‐ subgroup (18.17%) and in patients with Paget's disease (19.05%). SM was most frequently performed in patients with Paget's disease (29.00%), and MRM for ductal (64.99%), and lobular (63.78%) carcinomas. During the study period, the proportion of patients who underwent MRM dropped by 29.04%, SM and BCS increased from 15.78% and 30.83%, respectively, and NACT increased in all subgroups, particularly in patients with lymph node involvement (26.72%).ConclusionsSurgical modalities varied significantly by age and histologic group. The use of BCS and SM increased dramatically, while MRM declined significantly. The proportion of patients treated with NACT has increased significantly, especially in patients with lymph node involvement.

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Section: Discussionsupporting

confidence: 83%

“…62 BSC can be considered in patients with no presence of underlying neoplasm in the breast. 63,64 There is an increasing trend in patients with Paget's disease to consider BCS; 65 however, all efforts should be undertaken to ensure local control. 66 Surgical treatment of breast cancer in China has changed over time.…”

Section: Discussionmentioning

confidence: 99%

Present and changing trends in surgical modalities and neoadjuvant chemotherapy administration for female breast cancer in Beijing, China: A 10‐year (2006–2015) retrospective hospitalization summary report‐based study

et al. 2018

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“…The Paget's disease, an important differential diagnosis, is an intraepithelial adenocarcinoma [9], that represents 1-4% of all cases of breast cancer [4,9], and, it is presented, in most cases, with unilateral manifestations [4,10].…”

Section: Discussionmentioning

confidence: 99%

“…If the treatment is not effective or whether there is a suspicion of malignancy, the biopsy must be performed [7]. The wedge biopsy provides good results, since a part of the lactiferous duct can be excised together with the rest of the sample to perform the histopathological study [9].…”

Section: Discussionmentioning

confidence: 99%

Atopic Eczema Simulating Mammary Paget’s Disease in an Adult: Case Report

Nunes

Machado²,

Goiabeira³

et al. 2018

int arch med

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An atopic breast eczema is usually bilateral, with intense pruritus and good response to corticosteroids. The differential diagnosis with mammary Paget's disease is fundamental, mainly in unilateral clinical manifestations, since it is frequently associated to adjacent breast tumors. The aim of the present report was to present a clinical condition of an atopic breast eczema through an exuberant and unilateral clinical presentation, emphasizing the need of the differential diagnosis for malignant diseases at this location.

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“…2 In the presence of these features, Paget's disease of breast can be a diagnostic challenge as possibility of Paget's disease of breast is overlooked & diagnosis of dermatitis/eczema is made & treated with topical steroid. 2,4 Diagnosis hence remains elusive for long period.…”

Section: Introductionmentioning

confidence: 99%

Paget’s disease of breast with an unusual presentation of involvement of overlying skin of breast: a case report

Kumar¹,

Jindal²,

Bhalgat³

et al. 2020

Int Surg J

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Paget’s disease of breast is also known as Paget’s disease of the nipple & mammary Paget’s disease, involving the skin of nipple & areola. It is rare type of cancer with tumors inside the same breast which may be either ductal carcinoma in-situ or invasive breast cancer. We report a case with Paget’s disease of breast which is not only involving the nipple-areola complex but also involving surrounding skin of breast.

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Challenges in Diagnosis and Management of Paget’s Disease of the Breast—a Retrospective Study

Cited by 20 publications

References 22 publications

Present and changing trends in surgical modalities and neoadjuvant chemotherapy administration for female breast cancer in Beijing, China: A 10‐year (2006–2015) retrospective hospitalization summary report‐based study

Present and changing trends in surgical modalities and neoadjuvant chemotherapy administration for female breast cancer in Beijing, China: A 10‐year (2006–2015) retrospective hospitalization summary report‐based study

Atopic Eczema Simulating Mammary Paget’s Disease in an Adult: Case Report

Paget’s disease of breast with an unusual presentation of involvement of overlying skin of breast: a case report

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