Participation in syringe exchange programs (SEPs) is associated with many individual and public health benefits, but may have little impact on reducing drug use without concurrent treatment engagement. The present study evaluated rates of drug use, other risk behaviors, and illegal activities in newly registered SEP participants (n = 240) enrolled versus not enrolled in substance abuse treatment over a 4-month observation window, and examined the effect of days in treatment on these outcomes. After controlling for baseline differences, SEP registrants enrolled in treatment (n = 113) reported less days of opioid and cocaine use, injection drug use, illegal activities, and incarceration than those not enrolled in treatment (n=127). For those enrolled in treatment, days of treatment was strongly correlated with each of these outcomes. These findings provide good evidence for a dose-response effect of treatment in syringe exchangers, and suggest that substance abuse treatment significantly expands the harm reduction benefits of SEP participation.Keywords syringe exchange; substance abuse treatment; injection drug use; HIV risk behaviors; harm reduction
I.0 IntroductionCommunity syringe exchange programs (SEPs) are consistently associated with reduced rates of injection equipment sharing and reduced rates of HIV infection (e.g., Bluthenthal, Kral, Gee, Erringer, & Edlin, 2000;Des Jarlais et al., 1996;Des Jarlais, McKnight, Goldblatt, & Purchase, 2009;Gibson et al., 2002;Huo & Ouellet, 2007; see Wodak & Cooney, 2006 for a review). The fact that syringe exchange participation does not fully suppress the sharing of injection equipment is most likely related to the high rates of continuing drug injection in this subgroup of substance users (e.g., Des Jarlais, Braine, Yi, & Turner, 2007;Fisher, Fenaughty, Cagle, & Wells, 2003;Wood et al., 2002). Interventions that fully suppress drug injection would clearly enhance the harm reduction benefits of syringe exchanges. A recent study by Van Den Berg, Smit, Van Brussel, Coutinho, & Prins (2007) reached this conclusion in a study of 714 injection drug users in Amsterdam. Subjects in that study that concurrently participated in syringe exchange and substance Phone for First Author: Phone: (410) 550-0006, Fax: (410) 550-2957, mkidorf@jhmi.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. While several studies have reported on promising strategies to bridge syringe exchange and substance abuse treatment participation (Kidorf et al., 2009;Kuo et al., 2003;Strathdee et al., 2006), little is known about the responsiveness of syringe...