Challenges in Psychopharmacological Management of a Young Child with Multiple Comorbid Disorders, History of Trauma, and Early-Onset Mood Disorder: The Role of Lithium

Deepmala, _; Coffey, Barbara J.

doi:10.1089/cap.2014.2492

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…Anxiety disorders were one of the most comorbidity in their study [28]. Many case reports suggest that mood disorders may co occure with anxiety disorders and behavioral disorders [29]. Comorbidity of depression disorders and behavioral disorders reported by some researchers too [30].…”

Section: Discussionmentioning

confidence: 87%

A survey of Psychiatric Disorders and Their Comorbidities in Children and Adolescents

Heydari Yazdi,

Eslamzadeh,

Mohammadi

et al. 2023

GMJ

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Background: This community-based study aimed to investigate the psychiatric disorders and their comorbidities according to the kind of psychiatric disorders. Frequency of demographic factors and the prevalence of total psychiatric disorders in term of demographic charactheristics were obtained too. Materials and Methods: The present study focused on 1028 children and adolescent aged 6 to 18 years old across the Razavi Khorasan province by random sampling. The subjects included 496 boys and 532 girls from three age groups (6-9 years, 10-14 years and 15-18 years). Eight clinical psychologists trained to complete the Persian version of K-SADS-PL (Kiddie-SADS present and life time version). This scale measures five diagnostic appendixes of psychiatric disorders. Demographic data of participants were collected too. The data were recorded into the SPSS version 16. The relationship between psychiatric disorders and demographic factors deliberate by descriptive analysis and 95% confidence interval. Results: The total rate of psychiatric disorders among children and adolescent was estimated as 20.5%, elimination disorders with a rate of 12.9% was the most prevalent disorder in the subjects. The lowest prevalence belongs to psychotic disorder and bulimia nervosa (0.1%). Of participants with mood disorders about 71.4% have behavioral disorders too. Anxiety disorders also commonly occurred in person with mood disorders. The comparison of ORs and their 95% confidence interval revealed that there is a significant difference for total psychiatric disorder among boys and girls (OR=0.6 for girls; 95% CI: 0.44-0.82). The rate of total psychiatric disorders in rural and urban areas was 14.9% and 21.1% respectively. Conclusion: With attention to the high prevalence of psychiatric disorders among children and adolescents, itâ€™s necessary that healthcare officials pay more attention to reinforcement of mental health care. [GMJ.2020;9:e1714]

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Section: Discussionmentioning

confidence: 87%

A survey of Psychiatric Disorders and Their Comorbidities in Children and Adolescents

Heydari Yazdi,

Eslamzadeh,

Mohammadi

et al. 2023

GMJ

View full text Add to dashboard Cite

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“…For prediction of linear B cell epitopes, ABCpred ( ) [ 29 ], LBtope ( ) [ 30 ], SVMtrip ( ) [ 31 ] and IEDB( ) web servers were used. Thus, the predictions of epitopes were mostly on the basis of Chou and Fasman beta-turn [ 32 ], Karplus and Schulz flexibility [ 33 ], Emini surface accessibility [ 34 ], Parker hydrophilicity [ 35 ], and Kolaskar and Tongaonkar antigenicity [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Construction of A Synthetic Gene Encoding the Multi-Epitope of Toxoplasma gondii and Demonstration of the Relevant Recombinant Protein Production: A Vaccine Candidate

Karimi

Tabaei

Ranjbar

et al. 2020

GMJ

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Background: Toxoplasma gondii is a widely-distributed parasite all over the world whose attributed severe afflicting complications in human necessitate the development of serodiagnostic tests and vaccines for it. Immunological responses to monovalent vaccines and the application of diagnostic reagents including single antigens are not optimally effective. Bioinformatics approaches were used to introduce these epitopes, predict their immunogenicity and preliminarily evaluate their potential as an effective DNA vaccine and for serodiagnostic goals. Materials and Methods: A 3D structure of proteins was predicted by I-TASSER server, and linear and conformational B cell and T cell epitopes were predicted using the online servers. Then, the predicted epitopes were constructed and called Toxoeb, and their expression in the prokaryotic and eukaryotic cells was demonstrated using SDS-PAGE. In the next step, Western blotting with pooled sera of mice infected with T. gondii was done. Results: The current in silico analysis revealed that the B cell epitopes with high immunogenicity for GRA4 protein were located in the residues 34-71, and 230-266, for GRA14 in 308-387, for SAG1 in 182-195, 261-278, and for GRA7 in residues 101-120, 160-176. The T cell epitopes were selected in overlapping regions with the B cell epitopes. The immunogenic region for GRA4 are in the residues 245-253, 50-58, and 40-54, for GRA14 in 307-315, 351-359, and 308-322, for SAG1 261-269, and 259-267, and for GRA7 in the residues 103-112, and 167-175. The results of the western blotting showed that the expressed protein had immunogenicity. Conclusion: Our constructed multi-epitope of T. gondii could be considered as a candidate for diagnostic and vaccination purposes. [GMJ.2020;9:e1708]

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Prevalence and Correlates of Psychiatric Disorders in a National Survey of Iranian Children and Adolescents

Mohammadi

Ahmadi

Khaleghi

et al. 2019

IJPS

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Objective: Considering the impact of rapid sociocultural, political, and economical changes on societies and families, population-based surveys of mental disorders in different communities are needed to describe the magnitude of mental health problems and their disabling effects at the individual, familial, and societal levels. Method: A population-based cross sectional survey (IRCAP project) of 30 532 children and adolescents between 6 and 18 years was conducted in all provinces of Iran using a multistage cluster sampling method. Data were collected by 250 clinical psychologists trained to use the validated Persian version of the semi-structured diagnostic interview Kiddie-Schedule for Affective Disorders and Schizophrenia-PL (K-SADS-PL). Results: In this national epidemiological survey, 6209 out of 30 532 (22.31%) were diagnosed with at least one psychiatric disorder. The anxiety disorders (14.13%) and behavioral disorders (8.3%) had the highest prevalence, while eating disorders (0.13%) and psychotic symptoms (0.26%) had the lowest. The prevalence of psychiatric disorders was significantly lower in girls (OR = 0.85; 95% CI: 0.80-0.90), in those living in the rural area (OR = 0.80; 95% CI: 0.73-0.87), in those aged 15-18 years (OR = 0.92; 95% CI: 0.86-0.99), as well as that was significantly higher in those who had a parent suffering from mental disorders (OR = 1.96; 95% CI: 1.63-2.36 for mother and OR = 1.33; 95% CI: 1.07-1.66 for father) or physical illness (OR = 1.26; 95% CI: 1.17-1.35 for mother and OR = 1.19; 95% CI: 1.10-1.28 for father). Conclusion: About one fifth of Iranian children and adolescents suffer from at least one psychiatric disorder. Therefore, we should give a greater priority to promoting mental health and public health, provide more accessible services and trainings, and reduce barriers to accessing existing services.

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Challenges in Psychopharmacological Management of a Young Child with Multiple Comorbid Disorders, History of Trauma, and Early-Onset Mood Disorder: The Role of Lithium

Cited by 4 publications

References 43 publications

A survey of Psychiatric Disorders and Their Comorbidities in Children and Adolescents

A survey of Psychiatric Disorders and Their Comorbidities in Children and Adolescents

Construction of A Synthetic Gene Encoding the Multi-Epitope of Toxoplasma gondii and Demonstration of the Relevant Recombinant Protein Production: A Vaccine Candidate

Prevalence and Correlates of Psychiatric Disorders in a National Survey of Iranian Children and Adolescents

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