Challenges in the Cross-Sectional Assessment of Cardiovascular Risk in Children with Premature Adrenarche due to the Multifaceted Nature of Atherosclerosis

Uçar, Ahmet

doi:10.1159/000455851

Horm Res Paediatr

2017

DOI: 10.1159/000455851

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Challenges in the Cross-Sectional Assessment of Cardiovascular Risk in Children with Premature Adrenarche due to the Multifaceted Nature of Atherosclerosis

Ahmet Uçar¹

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2023

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Dehydroepiandrosterone sulfate levels at 7 years old and cardio-metabolic factors at 10 and 13 years old – the generation XXI birth cohort

Silva

Fontoura

Severo

et al. 2023

Journal of Pediatric Endocrinology and Metabolism

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Objectives Premature adrenarche is often linked to a cluster of endocrine-metabolic risk factors. Our objective was to explore the association of dehydroepiandrosterone sulfate (DHEAS) levels at age 7 with cardio-metabolic traits at ages 10 and 13, independently of adiposity and pubertal stage. Methods Longitudinal study of 603 individuals (301 girls/302 boys) from the Generation XXI birth cohort. DHEAS at age 7 was measured by immunoassay. Anthropometrics, pubertal staging, blood pressure, and metabolic outcomes were evaluated at ages 7, 10, and 13. Pearson correlations between DHEAS and cardio-metabolic traits (insulin, HOMA-IR, triglycerides, LDL-cholesterol, high-sensitivity C-reactive protein, and systolic and diastolic blood pressure) were computed. Path analysis was used to estimate the effect of DHEAS at age 7 on cardiometabolic traits at ages 10 and 13, adjusted for body mass index (BMI) z-score and Tanner stage. Results DHEAS at age 7 correlated positively with insulin and HOMA-IR at ages 7 and 10 in both sexes, and at age 13 in girls, but not in boys. In girls, DHEAS levels at age 7 directly influenced HOMA-IR at age 13, controlling for BMI and Tanner stage. In boys, DHEAS at age 7 did not influence HOMA-IR at ages 10 and 13. DHEAS at age 7 did not influence the other cardio-metabolic outcomes analyzed. Conclusions DHEAS levels in mid-childhood have a positive longitudinal association with on insulin-resistance that persists, in girls, but not in boys, at least until age 13. No association was found regarding dyslipidemia, hypertension, or low-grade inflammation.

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Dehydroepiandrosterone sulfate levels at 7 years old and cardio-metabolic factors at 10 and 13 years old – the generation XXI birth cohort

Silva

Fontoura

Severo

et al. 2023

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

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Challenges in the Cross-Sectional Assessment of Cardiovascular Risk in Children with Premature Adrenarche due to the Multifaceted Nature of Atherosclerosis

Cited by 1 publication

References 10 publications

Dehydroepiandrosterone sulfate levels at 7 years old and cardio-metabolic factors at 10 and 13 years old – the generation XXI birth cohort

Dehydroepiandrosterone sulfate levels at 7 years old and cardio-metabolic factors at 10 and 13 years old – the generation XXI birth cohort

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