We study knockout reactions with proton probes within a theoretical framework where ab initio Quantum Monte Carlo wave functions are combined with the Faddeev/Alt-Grassberger-Sandhas few-body reaction formalism. New Quantum Monte Carlo wave functions are used to describe 12 C, yielding, for the first time, results consistent with the experimental point rms radii, electron scattering data and (p,2p) total cross sections data. Our results for A ≤ 12 and (N − Z) ≤ 3 nuclei show that the theoretical ratios between the (i) ab initio and Mean Field Approximation theoretical cross sections, R σ , (ii) corresponding ratios between the spectroscopic factors, R Σ , summed over states below particle emission, depend moderately on the nucleon separation energy S N . These ratios are determined by a delicate interplay between the radii of the parent and the residual nuclei and the nucleon separation energy, and were found to be always smaller for the knockout of the more correlated deficient species nucleon. In the case of the symmetric 12 C nucleus, the theoretical ratios still appear to indicate that protons are more correlated than neutrons.