Challenges in the Pharmacotherapeutic Management of Pediatric Asthma

Ioniuc, Ileana; Miron, Ingrith; Lupu, Vasile Valeriu; Stârcea, Iuliana Magdalena; Azoicăi, Alice; Alexoae, Monica; Raileanu, Anca Adam; Dragan, Felicia; Lupu, Ancuța

doi:10.3390/ph15121581

Cited by 11 publications

(7 citation statements)

References 64 publications

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“…Regulation and Ethical Issues: The regulatory environment for IoT-enabled medical devices is changing, and compliance with applicable laws is crucial to ensuring patient safety and device effectiveness. To establish a balance between technological innovation and patient rights, ethical issues like data ownership, permission, and patient autonomy must also be taken into account (27).…”

Section: Challenges and Considerationsmentioning

confidence: 99%

Smart Inhalers: Harnessing Iot for Precise Asthma Management

Rakesh Margam

2024

ierj

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Effective management techniques are required for the widespread chronic respiratory disease known as asthma in order to reduce its negative effects on public health. Smart inhalers are a prime example of how the introduction of Internet of Things (IoT) technology has sparked creative solutions. In this essay, the seamless integration of IoT technology is used to elaborate on the transformational potential of smart inhalers in improving asthma management. The traditional approach to managing asthma relies on individualised prescription regimens that must be consistently followed. But obstacles including patient forgetfulness and insufficient real-time monitoring frequently prevent effective adherence, aggravating symptoms and lowering quality of life. Smart inhalers are the result of the confluence of IoT technology with asthma therapy, signalling a paradigm change. Smart inhalers, driven by IoT, offer a wide range of characteristics and signal a paradigm change in the treatment of asthma. (1) These gadgets can monitor medicine use, inhaler technique, and environmental triggers in real time since they include sensors and connection. Personalised therapy modifications are made possible by the real-time data creation that gives healthcare professionals insights into patient behaviour, adherence trends, and symptom development. The ability of smart inhalers to revolutionise medication adherence is one of their main benefits. (2)Patients are better able to maintain their regimens when they receive prompt guidance on how to use an inhaler and reminders to take prescription drugs as directed. The resultant decline in emergency room visits, hospital admissions, and asthma attacks is evidence of these devices' effectiveness. Healthcare professionals are empowered to quickly react and prevent the progression of symptoms thanks to the real-time data stream from smart inhalers. (3)Asthma care has advanced dramatically with the introduction of IoT-enabled smart inhalers, which are expected to improve asthma sufferers' medication compliance, symptom management, and overall quality of life. Predicted developments in smart inhaler technology, including artificial intelligence and predictive analytics, portend improved personalisation and therapeutic efficacy as the IoT environment changes. The promise of smart inhalers to reshape asthma care resonates deeply with the principles of patient education, engagement, and interdisciplinary collaboration among healthcare professionals, researchers, and technology developers, setting a promising trajectory for respiratory healthcare. (4)

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Section: Challenges and Considerationsmentioning

confidence: 99%

Smart Inhalers: Harnessing Iot for Precise Asthma Management

Rakesh Margam

2024

ierj

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“…These will be evaluated depending on the degree of impairment of each asthmatic patient, as well as the associated comorbidities. The main classes of drugs used in this regard are inhaled corticosteroids (ICS), ICS-formoterol, oral or intravenous corticosteroids, anticholinergics, short-acting beta 2-agonists (SABA), long-acting beta 2-agonists (LABA), leukotriene receptor agonists (LTRA), long-acting antimuscarinic agents (LAMA), non-selective phosphodiesterase inhibitors, mast cell stabilizers, and monoclonal antibodies (Omalizumab, Mepolizumab, Benralizumab, Dupilumab, Tezepelumab) [ 97 , 98 ]. In addition to these, current research emphasizes the importance of administering probiotics, prebiotics, and symbiotics, but also fecal microbiota transplantation in the regulation of the microbiota and in the management of bronchial asthma.…”

Section: Therapeutic Linesmentioning

confidence: 99%

The Footprint of Microbiome in Pediatric Asthma—A Complex Puzzle for a Balanced Development

Lupu,

Jechel,

Mihai

et al. 2023

Nutrients

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Considered to be of greater complexity than the human genome itself, the microbiome, the structure of the body made up of trillions of bacteria, viruses, and fungi, has proven to play a crucial role in the context of the development of pathological processes in the body, starting from various infections, autoimmune diseases, atopies, and culminating in its involvement in the development of some forms of cancer, a diagnosis that is considered the most disabling for the patient from a psychological point of view. Therefore, being a cornerstone in the understanding and optimal treatment of a multitude of ailments, the body’s microbiome has become an intensively studied subject in the scientific literature of the last decade. This review aims to bring the microbiome–asthma correlation up to date by classifying asthmatic patterns, emphasizing the development patterns of the microbiome starting from the perinatal period and the impact of pulmonary dysbiosis on asthmatic symptoms in children. Likewise, the effects of intestinal dysbiosis reflected at the level of homeostasis of the internal environment through the intestine–lung/vital organs axis, the circumstances in which it occurs, but also the main methods of studying bacterial variability used for diagnostic purposes and in research should not be omitted. In conclusion, we draw current and future therapeutic lines worthy of consideration both in obtaining and maintaining remission, as well as in delaying the development of primary acute episodes and preventing future relapses.

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“…The first treatment regimen is chosen according to the presence and frequency of day/night symptoms, the limitation of physical activity and the risk of exacerbations. Afterwards, it is based on the patient’s response to the administered treatment plan, asthma being classified as controlled, partially controlled or uncontrolled [ 33 ]. The choice of their optimal way of administration is made depending on the clinical form of asthma (detailed in Table 3 ).…”

Section: Treatmentmentioning

confidence: 99%

Current Approaches in the Multimodal Management of Asthma in Adolescents—From Pharmacology to Personalized Therapy

Lupu,

Jechel,

Fotea

et al. 2023

Biomedicines

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Asthma and adolescence are two sensitive points and are difficult to manage when they coexist. The first is a chronic respiratory condition, with frequent onset in early childhood (between 3 and 5 years), which can improve or worsen with age. Adolescence is the period between childhood and adulthood (12–19 years), marked by various internal and external conflicts and a limited capacity to understand and accept any aspect that is delimited by the pattern of the social circle (of the entourage) frequented by the individual. Therefore, the clinician is faced with multiple attempts regarding the management of asthma encountered during the adolescent period, starting from the individualization of the therapy to the control of compliance (which depends equally on the adverse reactions, quality of life offered and support of the close circle) and the social integration of the subject, communication probably having a more important role in the monitoring and evolution of the condition than the preference for a certain therapeutic scheme. Current statistics draw attention to the increase in morbidity and mortality among children with bronchial asthma, an aspect demonstrated by the numerous hospitalizations recorded, due either to an escalation in the severity of this pathology or to faulty management. The purpose of this article is to review the delicate aspects in terms of controlling symptoms and maintaining a high quality of life among teenagers.

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Challenges in the Pharmacotherapeutic Management of Pediatric Asthma

Cited by 11 publications

References 64 publications

Smart Inhalers: Harnessing Iot for Precise Asthma Management

Smart Inhalers: Harnessing Iot for Precise Asthma Management

The Footprint of Microbiome in Pediatric Asthma—A Complex Puzzle for a Balanced Development

Current Approaches in the Multimodal Management of Asthma in Adolescents—From Pharmacology to Personalized Therapy

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