Challenges in the treatment of a patient with toxic epidermal necrolysis associated with COVID ‐19: A case report

The role of treatment with plasma exchange therapy in two pediatric toxic epidermal necrolysis cases related to COVID‐19

“… 18 Also, there are studies in which primarily coronavirus infection is mainly held responsible for the etiology of SJS/TEN. 12 , 19 , 20 In addition, SJS/TEN was detected in two cases with acute respiratory distress syndrome compatible with COVID‐19 despite a negative COVID‐19 PCR test. 21 Like in the classical SJS/TEN, various opinions about immunosuppressive treatments are present in COVID‐19 related SJS/TEN cases, due to its effect on coronavirus infection.…”

“…9 Although cases of SJS/TEN have been reported after hydroxychloroquine, vaccine (mRNA [Biontech] and inactivated vaccine [Sinovac]) administration and during the clinical course of active COVID-19 disease, limited data is indicating the COVID-19 disease as a triggering factor. [10][11][12] Also, there are no pediatric cases of SJS/TEN associated with COVID-19 in the literature.…”

Concurrent Management of a Patient with Toxic Epidermal Necrolysis and Coronavirus Disease-19: A Case Presentation

“…We performed a literature search using the terms "toxic epidermal necrolysis", "severe acute respiratory syndrome-coronavirus-2" and "COVID-19 infection". There is a limited number of case reports concerning TEN and COVID-19 infection concurrently (5)(6)(7)(8). The inflammatory process induced by COVID-19 infection reduces the threshold of drug reaction and predispose the COVID-19 positive patients to TEN (6).…”

“…There is a limited number of case reports concerning TEN and COVID-19 infection concurrently (5)(6)(7)(8). The inflammatory process induced by COVID-19 infection reduces the threshold of drug reaction and predispose the COVID-19 positive patients to TEN (6). The treatment of TEN is usually supportive and IVIG is the most preferred treatment of choice.…”

Patients With Suspected Severe Adverse Reactions to COVID-19 Vaccination Admitted to Intensive Care Unit: A Case Report

“…Then, patients with extensive cutaneous involvement should be treated as a burn patient, with proper management of IV administration of fluids, nutritional support, and to prevent infections. The use of medications, including corticosteroids, is controversial, although IVIG has offered promising results (26,37,38). Again, like for TTS, the use of IVIG in SJS could be considered since IVIG interact with the effector function of T cells, B cells, and monocytes blocking the interaction of Fas (CD95) with its ligand (FasL, CD95L) (39).…”