2020
DOI: 10.21521/mw.6426
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Challenges in using anesthesia for open chest and aorta surgery in swine

Abstract: Anesthesia for aorta surgery in pigs remains challenging due to the requirements for mechanical ventilation and the need for maintaining adequate homeostasis. We report an improved anesthesia protocol in an in vivo animal model to test a novel bacterial nanocellulose (BNC) within the ‘Kardio-BNC’ trial. Forty-four 6-month-old DanBred pigs comprising 6 males and 38 females (body weight ca. 82 kg) underwent implantation of pericardium reconstructive patches (n = 8), thoracic aorta prostheses (n = 15), or bot… Show more

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Cited by 2 publications
(2 citation statements)
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“…Oral or intranasal administration of azaperone at a dose of 4 mg/kg induces sedation in piglets clinically comparable with an intramuscular administration of 2 mg/kg [38,39]. Deeper sedation with fewer adverse effects can be achieved by combining azaperone with ketamine and butorphanol [22,29] or azaperone with ketamine and an alpha-2 adrenergic agonist [30]. Susceptible Pietrain pigs were 100% protected against malignant hyperthermia with azaperone at doses of 0.5-2 mg/kg IM [11].…”
Section: Sedation and Premedicationmentioning
confidence: 99%
“…Oral or intranasal administration of azaperone at a dose of 4 mg/kg induces sedation in piglets clinically comparable with an intramuscular administration of 2 mg/kg [38,39]. Deeper sedation with fewer adverse effects can be achieved by combining azaperone with ketamine and butorphanol [22,29] or azaperone with ketamine and an alpha-2 adrenergic agonist [30]. Susceptible Pietrain pigs were 100% protected against malignant hyperthermia with azaperone at doses of 0.5-2 mg/kg IM [11].…”
Section: Sedation and Premedicationmentioning
confidence: 99%
“…Large animals such as pigs are often used in preliminary biocompatibility studies of new materials developed for use in medicine, including vascular and cardiac surgery. They were used in studies involving the implantation of reconstructive pericardial patches, thoracic aortic prostheses or both to determine BC biocompatibility (Kowalik et al, 2020). Individual operations were performed sequentially, depending on the increasing surgical complexity: pericardial patches, thoracic aortic prostheses, and a combination of both.…”
Section: Examples Of Bc Implant Application In Clinical Practice and ...mentioning
confidence: 99%