In the manufacturing of hypotubes for coronary applications, austenitic steels of types 304, 304, or 316 L are being used. The manufacturing process involves bending steel strips into tubes and the continuous longitudinal welding of the tubes. Manufacturing also includes heat treatments and stretching operations to achieve an external/internal diameter of 0.35/0.23 mm, with a tolerance of +/− 0.01 mm. Austenitic steels are sensitive to localized corrosion (pitting, crevice, and intergranular) that results from the welding process and various heat treatments. An extremely important step is the cleaning and the internal and external passivation of the hypotube surface. During patient interventions, there is a high risk of metal cations being released in contact with human blood. The aim of this study was to evaluate the state of passivation and corrosion resistance by using electrochemical methods and specific intergranular corrosion tests (the Strauss test). There were difficulties in passivating the hypotubes and assessing the corrosion phenomena in the interior of the tubes. Assessments were made by plotting the open circuit potential curves and exploring the polarization curves in the Tafel domain range of −50 mV vs Ecorr (redox potential) and +150 mV vs saturated calomel electrode (SCE, reference micro-electrode) for both the external and the internal surfaces of the hypotubes. The tested hypotubes did not exhibit intergranular corrosion, as mass losses were low and, in general, close to the limit of the analytical balance. Electrochemical techniques made the differentiation of the passivation state of the tested hypotubes possible. The measured currents were of the order of nano–pico amperes, and the quantities of electrical charges consumed for corrosion were of the order of micro–nano coulombs.