Challenges of Implementing New Remineralization Technologies

Pfarrer, Aaron M; Karlinsey, Robert L.

doi:10.1177/0895937409335643

Cited by 27 publications

(28 citation statements)

References 17 publications

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“…Fluoroapatite crystals have been reported to be relatively insoluble, allowing them to protect the enamel from further demineralisation [Peters, 2010]. Fluoride is the most widely used and the most efficient agent to aid remineralisation and prevent demineralisation of teeth, making it the reference agent against which new remineralisation agents are compared [Pfarrer and Karlinsey, 2009]. Nevertheless, the concentrations of fluoride utilized in over-the-counter toothpastes (around 1,000 ppm fluoride) may not be sufficient.…”

Section: Role Of Fluoride In the Prevention Of Dental Caries And Erosionmentioning

confidence: 99%

“…There may be some incompatibility issues between fluoride and CPP-ACP. In formulations containing the two substances, the availability of fluoride can decrease [Pfarrer and Karlinsey, 2009]. A practical solution to this issue includes physical separation with the use of a dual chamber packaging, formulation changes to minimise interactions between fluoride and CPP-ACP or the reduction of water content [Pfarrer and Karlinsey, 2009].…”

Section: Remineralisation Potential Of Cpp-acp On Carious Lesionsmentioning

confidence: 99%

“…In formulations containing the two substances, the availability of fluoride can decrease [Pfarrer and Karlinsey, 2009]. A practical solution to this issue includes physical separation with the use of a dual chamber packaging, formulation changes to minimise interactions between fluoride and CPP-ACP or the reduction of water content [Pfarrer and Karlinsey, 2009]. Nevertheless, it was reported that in a product such as MI Paste, ACP should not interact with fluoride, and precipitate as CaF, due to the relatively low fluoride concentration (900 ppm) [Gupta S MFP = Sodium monofluorophosphate; WSEL = white spot enamel lesions.…”

Section: Remineralisation Potential Of Cpp-acp On Carious Lesionsmentioning

confidence: 99%

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Biofunctional Properties of Caseinophosphopeptides in the Oral Cavity

Nongonierma

Fitzgerald

2012

Caries Res

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Caseinophosphopeptides (CPPs), bioactive peptides released from caseins, have the ability to enhance bivalent mineral solubility. This is relevant to numerous biological functions in the oral cavity (promotion of tooth enamel remineralisation, prevention of demineralisation and buffering of plaque pH). Therefore, CPPs may play a positive role as prophylactic agents for caries, enamel erosion and regression of white spot lesions. Most in vitro and in situ studies demonstrate strong evidence for the bioactivity of CPPs in the oral cavity. Nevertheless, relatively little is known concerning their use as adjuvants for oral health and more particularly regarding their long-term effects on oral health.

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Section: Role Of Fluoride In the Prevention Of Dental Caries And Erosionmentioning

confidence: 99%

Section: Remineralisation Potential Of Cpp-acp On Carious Lesionsmentioning

confidence: 99%

Section: Remineralisation Potential Of Cpp-acp On Carious Lesionsmentioning

confidence: 99%

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Biofunctional Properties of Caseinophosphopeptides in the Oral Cavity

Nongonierma

Fitzgerald

2012

Caries Res

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“…In contrast, the C1 symmetry site does not possess such defects within the calcium and phosphate polyhedra. Because the issue of compatibility with fluoride is paramount in the design of improved anti-caries therapies (Pfarrer and Karlinsey, 2009), the possibility of modifying, or functionalizing, β-TCP provides a prospective avenue in the research of bioactive and fluoridecompatible mineralizing agents. The purpose of functionalizing β-TCP with organic and/or inorganic molecules in this case is two-fold: First, it creates barriers that prevent premature fluoridecalcium interactions, and, second, it facilitates targeted delivery (Karlinsey et al, 2009b) when applied to the teeth via common dental preparations (e.g., dentifrice, mouthrinse, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, the continued prevalence of caries and the limitations of fluoride for dental erosion contribute to the need for improved practices and/or therapies. The clinically proven success and acceptance of fluoride for prevention and/or maintenance of dental decay suggest that one way of improving efficacy might be through improving fluoride's activity (Pfarrer and Karlinsey, 2009). In this paper, we describe our approach in enhancing fluoride's benefits through promising functionalized tricalcium phosphate (fTCP) ingredients.…”

mentioning

confidence: 99%

Fluoride Plus Functionalized β-TCP

Karlinsey

Pfarrer²

2012

Adv Dent Res.

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With more than 50 years of clinical success, fluoride serves as the gold standard agent for preventing tooth decay. In particular, the action of fluoride facilitates saliva-driven remineralization of demineralized enamel and alters solubility beneficially. Still, tooth decay remains problematic, and one way to address it may be through the development of new mineralizing agents. Laboratory and clinical studies have demonstrated that the combination of fluoride and functionalized β-tricalcium phosphate ( fTCP) produces stronger, more acid-resistant mineral relative to fluoride, native β-TCP, or fTCP alone. In contrast to other calcium-based approaches that seem to rely on high levels of calcium and phosphate to drive remineralization, fTCP is a low-dose system designed to fit within existing topical fluoride preparations. The functionalization of β-TCP with organic and/or inorganic molecules provides a barrier that prevents premature fluoride-calcium interactions and aids in mineralization when applied via common preparations and procedures. While additional clinical studies are warranted, supplementing with fTCP to enhance fluoride-based nucleation activity, with subsequent remineralization driven by dietary and salivary calcium and phosphate, appears to be a promising approach.

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Fluoride release and remineralizing potential of varnishes in early caries lesions in primary teeth

Soares‐Yoshikawa

Varanda

Iwamoto

et al. 2020

Microscopy Res & Technique

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This study evaluated the fluoride (F) release and remineralizing potential of varnishes containing sodium fluoride (5% NaF), 5% NaF with CPP‐ACP and 5% NaF with TCP in early caries lesions in primary teeth. To determine the F release at 1, 4, 6, 24, 72, and 168 hr, strips were covered with the varnishes and immersed in purified water (n = 7). The varnishes and purified water (negative control) were applied on enamel blocks with early caries lesions (n = 16). Enamel blocks were stored in artificial saliva and submitted to a pH‐cycling. The area of enamel hardness loss (ΔS) was analyzed by microhardness, lesion depth by polarized light microscopy (PLM) and the chemical analysis by Energy‐dispersive X‐ray spectroscopy. Data were submitted to Shapiro–Wilk, two‐way and one‐way ANOVA, Tukey and paired t‐tests (α = 5%). All varnishes released F, but 5% NaF with CPP‐ACP had the highest release at 4, 6, 24, and 72 hr (p < .05) followed by 5% NaF with TCP and 5% NaF. No significant difference in ΔS was observed among varnishes (5% NaF = 4,098.4 ± 1,407.9; 5% NaF with CPP‐ACP = 4,164.0 ± 1,019.3; 5% NaF with TCP = 4,183.2 ± 1,527.2; p = .999), but all of them differed from the negative control group (6,757.8 ± 2,274.7; p < .001). Lesion depth was lower in varnishes groups compared to negative control (% reduction: 5% NaF = 41.8%, 5% NaF with CPP‐ACP = 38.8%, and 5% NaF with TCP = 36.3%; p < .001). Similar Ca, P, and Ca/P ratio percentages among groups and F was not detected after the treatments. All fluoride varnishes showed potential to enhance remineralization of early caries lesions in primary teeth.

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Challenges of Implementing New Remineralization Technologies

Cited by 27 publications

References 17 publications

Biofunctional Properties of Caseinophosphopeptides in the Oral Cavity

Biofunctional Properties of Caseinophosphopeptides in the Oral Cavity

Fluoride Plus Functionalized β-TCP

Fluoride release and remineralizing potential of varnishes in early caries lesions in primary teeth

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