“…The use of DL in NM, referring to the physics part, includes disease diagnosis using PET [19], SPECT [20,21], imaging physics using PET [22], SPECT [23], image reconstruction using PET [24], SPECT [25], image denoising using PET [26,27], SPECT [28], image segmentation using PET [29], SPECT [30], and image classification using PET [31], SPECT [32]. Similar ideas are presented in [2,[33][34][35], where examples of specific ML capabilities include automated image segmentation, pre-analysis, and quantitation, radiomic feature extraction from image data, image reconstruction, case triage and reporting prioritization, research and data mining, and natural language processing. The second component, primarily application-driven, will be referred to as the 'clinical' component.…”