The incompatibility of N, P, and K rates for maize plants causes a decrease in plant productivity and farmer income. Therefore, there is a need for appropriate N, P, and K fertilizer recommendations based on agroecosystems that farmers can apply. This research aims to obtain location-specific N, P, and K fertilization recommendations for maize based on the agroecosystem in Jeneponto Regency, South Sulawesi. This research was conducted in Jeneponto District, South Sulawesi, from March to October 2021. The research used a survey method adapted to the questions in the Nutrient Expert (NE) program form. The research showed that the optimum fertilizer recommendation for maize in Jeneponto District was 170 – 190 kg N ha−1, 30 – 60 kg P2O5 ha−1, and 33 – 63 kg K2O ha−1, with a 9 – 10 t/ha yield. Using these recommendations, they will gain a higher profit and R-C ratio than the farmer’s existing fertilization, namely, a profit of RP. 30,499,400 (Rp. 30,276,000 – 30,697,000) with an R-C ratio of 4.05 (3.96 – 4.13), whereas if using existing fertilization at the farmer level, they will gain a profit of Rp. 19,397,000 (Rp. 14,215,000 – Rp. 25,735,000) with an R-C ratio of 2.20 (1.81 – 2.75).