Challenges of the Control of Opportunistic Infections of Zoonotic Origin in HIV/AIDS Patients

Adesiji, Yemisi Olukemi; Oloke, Julius Kola

doi:10.11648/j.iji.s.2015030201.11

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…Reports of human infections by B. bronchiseptica are limited to case reports or case report series 4 6–9. Immunocompromised states, for example, HIV, haematological malignancy or post-transplant immunosuppression makes humans vulnerable to zoonotic infections 1011–14…”

Section: Discussionmentioning

confidence: 99%

Chronic cough and cystic lung disease caused byBordetella bronchisepticain a patient with AIDS

Sameed¹,

Sullivan

Marciniak

et al. 2019

BMJ Case Rep

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A 24-year-old man with a history of HIV and large B cell lymphoma (currently in remission) presented with fever, dry cough and dizziness. His CD4+ count was undetectable, and the HIV viral load was 109 295 cop/mL. Physical examination revealed fever, hypotension and tachycardia with coarse breath sounds in the middle and lower chest zones bilaterally. Chest imaging showed diffuse abnormal micronodular and patchy infiltrates, without focal consolidation. A cavitary lesion was noted measuring 5×2 cm in axial dimensions within the left lower lobe and multiple small cystic lesions in the background. Bronchoalveolar lavage fluid culture grew Bordetella bronchiseptica. The patient was empirically treated with vancomycin and piperacillin–tazobactam for multifocal pneumonia with concerns for sepsis and was started on combined antiretroviral therapy (cART) with abacavir/dolutegravir/lamivudine. Symptoms improved after day 3 of therapy, and the patient was discharged home on 2 weeks of moxifloxacin, in addition to the cART and appropriate chemoprophylaxis.

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Section: Discussionmentioning

confidence: 99%

Chronic cough and cystic lung disease caused byBordetella bronchisepticain a patient with AIDS

Sameed¹,

Sullivan

Marciniak

et al. 2019

BMJ Case Rep

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Magnitude of opportunistic infections and associated factors among adult people living with human immune deficient virus on art at selected public hospital, mogadishu somalia: cross-sectional study

Mohamud¹,

Ahmed

Mohamud

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction: Opportunistic infections (OIs) remain the leading cause of death among people living with Human immune deficient virus and OIs-related mortality in Africa is estimated at 310 000 cases. Besides, Somalia has scant data about OIs since a high burden of tuberculosis and HIV co-infection has been reported. Hence, up-to-date information is vital for better treatment and interventions and may support national and international HIV strategies and eradication programs. Therefore, this study aims to estimate the magnitude of OIs and determine factors associated with among people living with HIV/AIDs on anti-retroviral therapy (ART) in a selected public hospital in Mogadishu, Somalia. Materials and methods: A hospital-based cross-sectional study was conducted between 1 June and 30 August 2022 by interviewing HIV patients and reviewing case record files using a validated questionnaire containing sociodemographic, clinical, OIs history, behavioural and environmental characteristics. Logistic regression was used to determine factors associated with OIs at the significance level of a=0.05. Result: The magnitude of OIs among people living with HIV was 37.1% (95% CI=31.6–42.2); major identified OIs were pulmonary tuberculosis 8.2%, Diarrhoea 7.9%, and Pneumonia 4.3%. Based on Multivariable logistic regression drinking non-sterilized water [adjusted odds ratio (AOR)=2.395, 95% CI: 2.010–4.168], living with domestic animals (AOR=4.012, 95% CI: 1.651–4.123), Co-morbidity of chronic disease (AOR=2.910, 95% CI: 1.761–3.450), and poor ART adherence (AOR=3.121, 95% CI: 1.532–6.309) were factors associated with OIs. Conclusion: Human immune deficient virus patients in Mogadishu, Somalia, suffer from OIs. The OIs reduction strategies should improve drinking water sanitation, provide special consideration for those living with domestic animals and those with a co-morbid chronic disease, and improve ART adherence.

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Challenges of the Control of Opportunistic Infections of Zoonotic Origin in HIV/AIDS Patients

Cited by 2 publications

References 49 publications

Chronic cough and cystic lung disease caused byBordetella bronchisepticain a patient with AIDS

Chronic cough and cystic lung disease caused byBordetella bronchisepticain a patient with AIDS

Magnitude of opportunistic infections and associated factors among adult people living with human immune deficient virus on art at selected public hospital, mogadishu somalia: cross-sectional study

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