Challenges of transcranial photoacoustic imaging for human at 2.25 MHz: an ex vivo study

Saint-Martin, Loïc; Zafar, Mohsin; Manwar, Rayyan; Avanaki, Kamran

doi:10.1117/12.2613034

Cited by 4 publications

(4 citation statements)

References 54 publications

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“…To address limited coverage and enhance imaging of a larger area, we have introduced a simple multi-field-of-view (FOV) system. Instead of using a single angle transducer used in other works like [46,47] , we employ three transducers, each covering a specific imaging area within the ring. The transducers are tilted at calculated angles based on the ring radius and radial size of the FOV [41]:…”

Section: Methodsmentioning

confidence: 99%

Photoacoustic computed tomography with improved quality

Ranjbaran,

Zafar,

Saint-Martin

et al. 2024

Photons Plus Ultrasound: Imaging and Sensing 2024

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This paper introduces an innovative approach to enhance the circular scanning-based photoacoustic tomography (CS-PAT) system for photoacoustic imaging. The proposed method involves using a circular detection geometry with three carefully placed ultrasound transducers (USTs). By strategically selecting the angles of the USTs, the field of view (FOV) is expanded, and tangential resolution is improved without requiring additional imaging time. The new CS-PAT system demonstrates practicality and convenience, providing higher signal-to-noise ratio and better structural similarity compared to the conventional system. This approach overcomes the limitations of the limited size of USTs and widens the application potential of CS-PAT in a straightforward and efficient manner.

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Section: Methodsmentioning

confidence: 99%

Photoacoustic computed tomography with improved quality

Ranjbaran,

Zafar,

Saint-Martin

et al. 2024

Photons Plus Ultrasound: Imaging and Sensing 2024

Self Cite

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show abstract

“…Once the simulation is done, the absorbed energy by the hemorrhage model is isolated (figure 2a), creating the source of the PA excitation for the acoustic propagation. 2.0 [67,68] 0.05 [18] 0.3 [18] 1.146 [18] 1.146 [18] 0.667 [18] Absorption coef.…”

Section: Methodsmentioning

confidence: 99%

“…(1/mm) 0.002 [18] 0.0001 [67,68] 0.001 [18] 0.0003 [18] 0.0006 [18] 0.0006 [18] 0.0399 [18] To simulate the propagation of acoustic waves for different configurations, we use k-Wave toolbox [58] operating on MATLAB and designed for simulation and reconstruction of PA wavefields. The electromagnetic energy (here generated by the light sources) is converted when reaching the target, a heat distribution is generated inside the target, creating a pressure wavefield.…”

Section: Methodsmentioning

confidence: 99%

Photoacoustic imaging for detection of blood clot with different sizes in the brain

Saint-Martin,

Ranjbaran,

Avanaki

2024

Photons Plus Ultrasound: Imaging and Sensing 2024

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During medical investigations of the head, the presence of skull bone constitutes a major challenge in generating accurate diagnostics. Photoacoustic imaging technology, with its functional imaging capabilities, has demonstrated the potential for brain imaging at low cost and with low maintenance requirements. While photoacoustic signal generation in deep tissue and through the skull has been demonstrated, an effective method of aberration correction for transcranial photoacoustic imaging has not yet been developed. In this study, we present a method based on enfolded deep learning algorithms that accurately compensates for acoustic aberrations caused by the head layers, allowing hemorrhage detection. Using a realistic simulated framework, a large quantity of aberrated images is acquired, reconstructed, and corrected.

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“…The diploe, in particular, causes acoustic distortion because of its highly variable acoustic medium (bone-fluid interfaces) and irregular bone structure. In adults, the thickness of the diploe, which can reach up to 8mm [31][32][33], reduces the intensity of the incident signal due to high acoustic absorption [28,34,35]. At the same time, the porosity of the diploe, or the volume of fluid in the layer, creates reverberation due to impedance mismatch at the interfaces [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Relationship between skull phantoms physical characteristics and acoustic wave signal features

Saint-Martin¹,

Aggrawal²,

Manwar³

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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During medical investigations of the head, ultrasound measurements can offer information with simple, non-invasive, and real-time procedure. However, for human adult applications, the clinical treatment of transcranial acoustic imaging remains a challenge by the presence of the skull, results in acoustic aberrations caused by two main phenomena, i.e., attenuation and distortion. These aberrations may affect the signal understanding because of the induced artifacts and the inaccuracy of the imaging target structural information. Variations of the physical properties of the skull, its thickness and porosity, will strongly affect the mechanical properties of the medium and thus the acoustic response. We propose a method to understand the influence of these characteristics on the signal degradation. In order to mimic the human adult skull, a large quantity of epoxy resin-based phantoms is created to explore all the possible physical characteristic variation in the bone. Additional components, titanium dioxide and seeds, will be added to the samples to recreate the acoustic scattering effects of a skull bone. Signal features from pulse-echo mode ultrasound, such as signal attenuation or broadening, will be extracted and studied in the time and frequency domain. In this paper, we are looking for relationship between these physical parameters and the signal features, with the objective to determine bone characteristics without any direct access in later experiments; and going a step further into aberration correction during transcranial imaging procedure.

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Challenges of transcranial photoacoustic imaging for human at 2.25 MHz: an ex vivo study

Cited by 4 publications

References 54 publications

Photoacoustic computed tomography with improved quality

Photoacoustic computed tomography with improved quality

Photoacoustic imaging for detection of blood clot with different sizes in the brain

Relationship between skull phantoms physical characteristics and acoustic wave signal features

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