Challenges, opportunities and recent advances in near infrared spectroscopy applications for monitoring blend uniformity in the continuous manufacturing of solid oral dosage forms

Dissolution profile prediction of sinomenine hydrochloride sustained release tablets, part II: a multisource data fusion approach

“…3 Currently, several studies have reported the effect of compression forces, 13 formulation composition, 14 particle size 15 and lubrication time 16 on dissolution using NIR spectroscopy. In addition, thus far, NIR spectroscopy has also been used for monitoring different manufacturing processes such as blending, 17 tableting, 18 and coating. 19 Recently, Raman spectroscopy has emerged as an alternative to NIR spectroscopy in process measurements.…”

Prediction of dissolution profiles of sinomenine hydrochloride sustained-release tablets part I: using near-infrared spectra as predictors

“…12 Spectroscopic techniques, such as near-infrared (NIR) or Raman spectroscopy, provide a nondestructive and cost-effective means, and have been widely recognized as powerful PAT tools applied in the pharmaceutical industry. 13 More recently, NIR spectroscopy has emerged as one of the most popular measurement methods, which can monitor blend uniformity, 14 tablet strength, 15,16 drug dissolution, 17 powder density 18 and adulteration 19 and has attracted increasing attention. Ojala et al used the design of experiments (DoE) approach to study the effects of variables systematically and substituted a conventional sixsample dissolution analysis of Toremifene 80 mg immediate release tablets by non-invasive NIR scanning of the production batches.…”

Veering to a Continuous Platform of Fused Deposition Modeling Based 3D Printing for Pharmaceutical Dosage Forms: Understanding the Effect of Layer Orientation on Formulation Performance

“…This practical limitation is majorly due to the confined print bed area of most FDM 3D printers, which also limits the applicability to a personalized on-demand application [ 15 , 16 , 17 ]. Furthermore, the involvement of a manual intervention followed by post-processing steps and collection makes it unfavorable for scaling up and bringing the printed dosage forms to the market [ 18 , 19 ].…”