Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer

Abstract

Inflammatory breast cancer is a rare, yet highly aggressive form of breast cancer, which accounts for less than 5% of all locally advanced presentations. The clinical presentation of inflammatory breast cancer often differs significantly from that of noninflammatory breast cancer; however, immunohistochemistry reveals few, if any, distinguishing features. The more aggressive triple-negative and HER2-positive breast cancer subtypes are overrepresented in inflammatory breast cancer compared with noninflammatory breast cancer, with a poorer prognosis in response to conventional therapies. Despite its name, there remains some controversy regarding the role of inflammation in inflammatory breast cancer. This review summarises the current molecular evidence suggesting that inflammatory signaling pathways are upregulated in this disease, including NF-κB activation and excessive IL-6 production among others, which may provide an avenue for novel therapeutics. The role of the tumor microenvironment, through tumor-associated macrophages, infiltrating lymphocytes, and cancer stem cells is also discussed, suggesting that these tumor extrinsic factors may help account for the differences in behavior between inflammatory breast cancer and noninflammatory breast cancer. While there are various novel treatment strategies already underway in clinical trials, the need for further development of preclinical models of this rare but aggressive disease is paramount.

Anti-inflammatory Mechanism of Rhein in Treating Asthma Based on Network Pharmacology

“…EERB2 can induce IL-6 autocrine activity, which in turn affects the JAK-STAT pathway-or NF-κB pathway-mediated in ammatory responses [33]. It is speculated that rhein interacts with EERB2 and may exert anti-in ammatory effects by regulating the secretion of IL-6 [34,35,36].…”

Inflammation and Breast Cancer: A Mini Review

“…The inflammation recruits immune cells which release the cytokines and chemokines which provide seed and soil microenvironment to facilitate metastasis such as Epithelial-to-Mesenchymal transition (EMT) [14][15][16].…”

Inflammation and breast cancer

“…Most of patients with IBC have advanced-stage disease by the time they begin treatment. The inflammation recruits immune cells which release the cytokines and chemokines which provide seed and soil microenvironment to facilitate metastasis such as Epithelial-toMesenchymal transition (EMT) [13][14][15].…”